m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
gross necropsy-survivors: no significant findings
gross necropsy-decedents: hyperemia of lungs and kidneys
Reliability : (2) valid with restrictions
no information about strain used, statistical evaluation not given
Flag : Critical study for SIDS endpoint
06.02.2004 (116)
Type : LD50
Value : = 2830 mg/kg bw
Species : rabbit
Strain :
Sex : female
Number of animals : 3
Vehicle : no data
Doses :
Method : other: see freetext ME
Year : 1977
GLP : no data
Test substance : other TS: m-cresol, not specified further
Method : The method used was essentially that of Smyth et al. 1962 (Am. Ind. Hyg.
Ass. J. 23, 95-107) except three females/dose were tested 24 hr occlusive
exposure to the neat material was followed by a 14-day observation period.
the most probable LD50 value was determined by the method of
Thompson 1947 (Bact. Rev.11, 115-145) of moving averages. Clinical
signs and purity of the Ts are not reported.
Reliability : (2) valid with restrictions
no guideline study: Doses used, clinical signs and purity of Test substance
are not reported
Flag : Critical study for SIDS endpoint
06.02.2004 (123)
Type : LD50
Value : = 1860 mg/kg bw
Species : rabbit
Strain :
Sex : male
Number of animals : 10
Vehicle : other: undiluted
Doses :
Method : other: application to the slipped trunk of rabbits for 24 hours under 'Vinylite'
sheeting, gross examination
Year : 1949
GLP : no
Test substance : other TS: purity no data
Remark : original data: 1.80 ml/kg
severe necrosis and erythema of the skin and kidney damage
(bloody urine in the urinary bladder), congested pancreas,
mottled liver and abdominal wall hemorrhagia were noted
Reliability : (4) not assignable
documentation insufficient for assessment
18.09.2002 (120)
5.1.4 ACUTE TOXICITY, OTHER ROUTES
Type : LD50
Value : = 168 mg/kg bw
Species : mouse
Strain :
UNEP PUBLICATIONS 127