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m-Cresol - ipcs inchem

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OECD SIDS<br />

p-CRESOL<br />

4. ECOTOXICITY ID: 106-44-5<br />

DATE: 24.05.2004<br />

Unit : mg/l<br />

LC50 : = 15.5<br />

Limit test :<br />

Analytical monitoring : no<br />

Method :<br />

Year : 1969<br />

GLP : no<br />

Test substance : other TS: p-cresol, purity of "practical grade"<br />

Method : 10 acclimated fish exposed per concentration, 20 served as<br />

control<br />

Result : LC50 (24 h) = 60.3 mg/l<br />

LC50 (48 h) = 50.8 mg/l<br />

at concentrations of 30 to 150 mg/l, the approximate<br />

incidences of surfacing were 30% during the first 10 minutes<br />

Test condition : 12 degrees C; reconstituted water<br />

Reliability : (2) valid with restrictions<br />

Study in accordance with generally accepted scientific<br />

standards and described in sufficient detail<br />

07.05.2004 (80)<br />

Type : flow through<br />

Species : Oncorhynchus mykiss (Fish, fresh water)<br />

Exposure period : 96 hour(s)<br />

Unit : mg/l<br />

LC50 : = 7.5<br />

Limit test :<br />

Analytical monitoring : yes<br />

Method : other<br />

Year : 1984<br />

GLP : no data<br />

Test substance : other TS: p-cresol, purity not noted<br />

Method : Bioassays were conducted at 0 (control), 10, 18, 32, 56, and<br />

100% of the maximum test concentration. Ten fish were<br />

exposed at each concentration. The fish weighed between 1<br />

and 4 g each. Bioassays were repeated 3 times. Chemicals<br />

were added to the water by a Hamilton Syringe pump to create<br />

the 100% concentration. Dilutions were done by a<br />

Mount-Brungs diluter. Each bioassay tank contained 14<br />

liters of water and the flow per tank varied between tests<br />

from 21 to 111 ml/min, depending upon how much chemical was<br />

available. The tanks were not aerated, to reduce<br />

volatilization. The levels in water of most water-soluble<br />

test compounds were measured daily. The assay method was<br />

the measurement of the absorbance of the ultraviolet light<br />

by the test solutions in a quartz cell with a 1 cm path<br />

length. Concentrations were calculated by reference to<br />

standard curves of the chemical dissolved in the control<br />

tank water.<br />

Reliability : (2) valid with restrictions<br />

Study in accordance with generally accepted scientific<br />

standards and described in sufficient detail<br />

07.05.2004 (81)<br />

Type : flow through<br />

Species : Pimephales promelas (Fish, fresh water)<br />

Exposure period : 96 hour(s)<br />

Unit :<br />

Limit test :<br />

Analytical monitoring : no<br />

UNEP PUBLICATIONS 227

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