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OECD SIDS m- / p-CRESOL MIXTURE 5. TOXICITY ID: 15831-10-4 DATE: 24.05.2004 At study termination, weights (w) were sign. increased: brain (males: rel. w. at 30000 ppm, p
OECD SIDS m- / p-CRESOL MIXTURE 5. TOXICITY ID: 15831-10-4 DATE: 24.05.2004 temperature: 72° +/-3° F, humidity: 50 % +/-15 %, Fluorescent light: 12 hrs/day, room air changes : 10-12 changes/hr TYPE AND FREQUENCY OF OBSERVATION: observed twice daily, body weight taken initially, weekly, and at termination, feed consumption by cage recorded twice weekly NECROPSY AND HISTOLOGIC EXAMINATION: necropsy and tissue collection performed for all animals. A complete histopathologic examination was conducted on all control animals, all animals in the highest dose group with at least 60 % survivors at study termination, and all aninmals in higher dose groups inclusive of early deaths. The following organs and/or tissues were included in complete histopathological examinations, as well as any tissue masses, gross lesions, and associated regional lymph nodes: adrenals, aorta, bone (sternebrae, femur, or vertebrae, including marrow), brain, bronchi, clitoral gland, epididymis, oesophagus, gallbladder, heart, kidney, large intestines (caecum, colon, rectum), liver, lungs, lymph nodes (mesenteric), mammary glands, nasal cavity and turbinates, oral cavity, ovaries, pancreas, parathyroids, pharynx, pituitary, preputial gland, prostate, salivary glands, scrotal sac, seminal vesicles, skin, small intestine (duodenum, ileum, jejunum), spleen, stomach, testes, thymus, thyroid, tongue, trachea, tunica vaginalis, urinary bladder, uterus and Zymbal's glands. Target organs and gross lesions were examined at lower doses until a no-observed chemical effect was determined. Target organs included the following: nasal epithelium, bone marrow, forestomach, oesophagus, lung and uterus and ovaries. Organ weights recorded for brain, liver, right kidney, thymus, heart, and lungs of all animals, and the right testis of all males. STATISTICAL METHODS: nonparametric multiple comparison test of Dunn and Shirley, Jonckheere's test Remark : mean compound consumption (mg/kg bw/day): males females 0 ppm 0 0 300 ppm 50 65 1000 ppm 161 200 3000 ppm 471 604 10000 ppm 1490 1880 30000 ppm 4530 4730 Result : No effect on survival; clinical signs of toxicity in males and females: alopecia, dehydration, hunched posture, hypothermia, lethargy, rough hair coat, thin appearance. 30000 ppm, males, females: weight loss; decreased feed consumption during the first week and during the third week (females only); 30000 and 10000 ppm: sign. decreased weight gain, At study termination weights (w) were sign. increased: brain (male, female: abs. and rel. w at 30000 ppm, p
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
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OECD SIDS m-CRESOL 3. ENVIRONMENTAL
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OECD SIDS m- / p-CRESOL MIXTURE I U
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OECD SIDS m- / p-CRESOL MIXTURE 1.
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m-Cresol - ipcs inchem

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