m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
specific duration of exposure:
m-cresol: MRL = 0.05 mg/kg bw/d acute oral exposure
Reliability : (4) not assignable
15.01.2003 (176)
Remark : It is reported that certain individuals are hypersensitive to
cresol (isomer not specified, no further information)
Reliability : (4) not assignable
Flag : Critical study for SIDS endpoint
15.01.2003 (110)
Remark : Case reports: intentional or accidental oral intake of cresols (all isomers):
irritation of mouth and throat, abdominal pain, vomiting, hemolytic anemia,
increased heart ratem liver and kidney damage, headaches, facial
paralysis, drowsiness, cramps coma and death
Reliability : (2) valid with restrictions
description suffers from deficiencies as the isomers are not specified
Flag : Critical study for SIDS endpoint
14.01.2003 (177) (178) (179) (180)
Remark : Skin depigmentation (chemical leukoderma has been reported after local
exposure to cresols (isomer not specified)
Reliability : (4) not assignable
Flag : Critical study for SIDS endpoint
15.01.2003 (130)
Remark : It is reported that skin contact has alo resulted in effects on the nervous
system, liver and kidneys and caused human fatalities.
Reliability : (4) not assignable
Flag : Critical study for SIDS endpoint
15.01.2003 (179)
Remark : A cresol solution, unintentionally poured over the trunk, caused gross
hematuria, gastrointestinal bleeding, hypertension and septic shock with
severe jaundice and renal failure.
Reliability : (2) valid with restrictions
Flag : Critical study for SIDS endpoint
15.01.2003 (181)
Remark : The development of tumours in persons who had been exposed
occupationally to cresol (unspecified isomer) has been reported, and two
cases of transitional cell bladder carcinoma were described after longterm
exposure to cresol. Since no information on exposure levels are available
and since co-exposure to other substances cannot be excluded a
carcinogenic potential of the cresol isomers cannot be deduced fron these
cases.
Reliability : (2) valid with restrictions
Flag : Critical study for SIDS endpoint
15.01.2003 (182)
Remark : Case report: a worker in an oil rafinery was exposed to cresol,
dichlorooctane and chromic acid for a long period developed a squamous
epithelial carcinoma of the vocal cords. Since no information on exposure
levels is available and since co-exposure to other substances is included a
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