m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Doses
Males :
Females : 10 mg/m3, 4 hrs a day for 100 d up to 4 months
Vehicle :
Route of administration : inhalation
Exposure time : 4 hour(s)
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
Deg. product :
Method :
Year :
GLP :
Test substance : other TS: m-cresol, not specified further
Result : Female rats were exposed to 10 mg/m3 m-cresol 4 hours per
day, daily for 100 d up to 4 months. m-Cresol reached a
concentration of 12.2 ug/g lung tissue; the neutral red
sorption on day 3 resp d 39 was 133 % resp. 152 % of the
control value as a marker for cytotoxicity. Full recovery
did not occur.
Reliability : (2) valid with restrictions
information on absorption via lung, but study description suffer from
deficiencies
Flag : Critical study for SIDS endpoint
06.02.2004 (115)
5.1.1 ACUTE ORAL TOXICITY
Type : LD50
Value : 242 mg/kg bw
Species : rat
Strain :
Sex : male
Number of animals : 5
Vehicle : other: none
Doses :
Method : other: 5 rats/dose group, 4 doses, undiluted liquid, time of recovery: up to
14 days
Year : 1969
GLP : no data
Test substance : other TS: m-cresol, purity not given, M.P.: 11-12 C, B.P.: 202,8 C
Result : dosage onset of sympt. mortality mortality
mg/kg bw 0-4 hrs 0-4hrs day3 day6 day7 cumulat.
147 S 0/5
215 S 1/5 1/5 2/5
316 S 3/5 1/5 4/5
464 S 4/5 1/5 5/5
S=signs of intoxication: Hypoactivity, tremors, convulsions,
salivation, prostration
survivors: recovery within observation time, gross necropsy:
no significant findings
UNEP PUBLICATIONS 121