m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
06.02.2004 (130)
Type :
Species : mouse
Sex : female
Strain : other: CBA/J
Route of admin. : dermal
Exposure period : 6 w
Frequency of treatm. : 3 times/week
Post exposure period : 6 months
Doses : 0.5 % in acetone
Control group : yes
Method : other: 5 rats, application of the substance to depilated or clipped lower
back by mist spray; observation of the hair colour of the new hair regrowth
were made weekly
Year : 1974
GLP : no data
Test substance : other TS: no data on purity
Result : No depigmentations of the regrowthed hair were observed.
Reliability : (4) not assignable
special study
18.09.2002 (132)
5.5 GENETIC TOXICITY ‘IN VITRO‘
Type : Sister chromatid exchange assay
System of testing : human lymphocytes
Test concentration : 0 -1.0 mM
Cycotoxic concentr. : no data
Metabolic activation : no data
Result : negative
Method : other: see freetext ME
Year : 1986
GLP : no data
Test substance : other TS: purity: 99.2 %
Method : Lymphocyte fraction from healthy donors were grown in Medium 199 with
Earles salts. After 24 hrs of cultur m-Cresol diluted in DMSO was added for
88-90 hrs.
Positive control: Styrene-7,8-oxide
Statistical Method: Linear regression analysis
Remark : Results of the positive control or solvent control in comparison to p-cresol
were not given.
Reliability : (2) valid with restrictions
Study description suffers from deficiencies: no information about
cytotoxicity and wether a metabolic activation system was used or not, only
summary results given
05.02.2004 (133)
Type : Ames test
System of testing : Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
Test concentration : up to 2 mg/plate (solubility limit); vehicle: water
Cycotoxic concentr. : not cytotoxic
Metabolic activation : with and without
Result :
140
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