m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
NOAEL maternal tox. : ca. 5 mg/kg bw
NOAEL teratogen. : ca. 100 mg/kg bw
Method : other: following the TSCA Health Effects Test guidelines for Specific
Organ/Tissue Toxicity - Developmental Toxicity (EPA, 1984,1987)
Year : 1988
GLP : yes
Test substance : other TS: m-cresol, purity: 99.7 %
Method : Dose selection was based on the results of a range-finding study.
14 mated females/group, 28 control females, all females were weighed ond
gd 0, 6, 12, 18, 24 and 29, food consumption was measured throughout
gestation, all females were examined daily for clinical signs, for mortality
and morbidity
sacrifice on gd 29:
does were evaluated for body weight, liver and gravid uterine weight,
number of corpora lutea and number of status of implantation sites (i.g.
resorptions, dead fetuses, live fetuses)
live fetuses were dissected from uterus, counted and weighed, examined
for external malformations and variations, and for visceral malformaltions
and variations, and for soft tissue craniofacial malformations
statistical analysis:
Levene's test, ANOVA, pooled t-test, Kruskal-Wallis test, Mann-Whitney U-
test, Fisher's exact test
Result : >= 50 mg/kg: audible respiration and ocular discharge
No embryotoxicity or teratogenicity was observed at any
dosage employed.
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
06.02.2004 (158)
Species : rat
Sex : female
Strain : Wistar
Route of admin. : s.c.
Exposure period : day 7 through day 17 of gestation
Frequency of treatm. : daily
Duration of test : until post partum
Doses : 90 mg/kg bw/d (30 ml/kg bw 0.3 %)
Control group : yes
Result : m-cresol was used as the solvent at a concentration of 0.3
%; no negative effects on F0- or F1-generation were observed
when compared with control animals.
Reliability : (3) invalid
application route is not relevant for the human situation
12.11.2002 (159)
Species : rat
Sex : female
Strain : Wistar
Route of admin. : s.c.
Exposure period : day 17 of gestation until 21 days after birth
Frequency of treatm. : daily
Duration of test : until 8 w post partum
Doses : 90 mg/kg bw/d (30 mg/kg 0.3 %)
Control group : yes
Result : m-cresol was used as the solvent at a concentration of 0.3
%; no negative effects on F0-, F1- or F2-generation were
observed when compared with controls (no fetotoxicity,
normal postnatal development, normal behaviour and
UNEP PUBLICATIONS 153