m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL MIXTURE
5. TOXICITY ID: 15831-10-4
DATE: 24.05.2004
Reliability : (2) valid with restrictions
16.01.2003 (107)
Remark : Case Report: A 74 old widow died after ingestion of an
overdose of lysol. Post morten findings: lower third of the
oesophagus and the whole of the stomach lining were bleached
white, areas of mucosal desquamation, pylorus and duodenum
showed a marked degree of congestion; 30.4 mg/100 ml mixed
cresols in the urine, 48.0 mg/100 g mixed cresols in the
liver; 19.0 mg/100 ml mixed cresols in the blood.
Reliability : (2) valid with restrictions
16.01.2003 (108)
Remark : A 76 year old unmarried woman swallowed an unknown quantity
of lysol. She was found shortly afterwards unconscious, and
despite resuscitative measures, she died within 2 hours;
post mortem findings: oesophagus, denuded of mucosa, was
deep purple; stomach dilated, containing 500 ml chocolate -
coloured fluid, mucosa: dark brown, necrotic; small
perforations on the anterior gastric wall; trachea and
bronchi with mucosal oedema, lungs congested; 90 mg mixed
cresols/100 g liver; 39.6 mg mixed cresols/100 g kidney ;
7.1 mg mixed cresols/100 ml blood.
Reliability : (2) valid with restrictions
16.01.2003 (108)
Remark : Case report: A 46 year old labourer, working in a chemical
factory, had a cresol solution poured over his upper trunk
when he was transporting a tub containing hot cresol. The
lesion consisted of a light brown eschar with well-defined
margine, minimal oedema. He developed gross haemeturia,
oliguria and finally anuria within 24 h, upper
gastrointestinal bleeding within 2 days, on day 4
progressive dyspnoe and tachypnoe, hypertension with blood
pressure arround 200/100 mmHg during the first 10 days. On
day 15 he developed a septic shock with severe jaundice and
renal failure. He was treated successfully and discharged on
day 38 after injury.
Reliability : (2) valid with restrictions
16.01.2003 (109)
Remark : Case Report: A man (50 years old) has drunk cresol solution
to commit suicide. 2 hours later he was found to be
unconscious, cyanotic with methemoglobinemia, blood pressure
90-136 mm Hg; pulse 101/min; light reflex: slow; urine
colour: black brown. Methb increased in the patients blood
drastically within 15 hours. He was treated successfully.
Reliability : (2) valid with restrictions
16.01.2003 (110)
Remark : Workers exposed to organic solvents (i.e. cresol) showed
increased levels of cresol, hippuric acid and phenols in
urine and decreased levels of albumiun and delta-globulin in
the serum.
Reliability : (4) not assignable
16.01.2003 (111)
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