m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
number of corpora lutea and number and status of implantation sites (i.e.
resorptions, dead fetuses, live fetuses)
live fetuses were dissected from uterus, counted and weighed, examined
for external malformations and variations, and for visceral malformaltions
and variations, and for soft tissue craniofacial malformations
statistical analysis:
Levene's test, ANOVA, pooled t-test, Kruskal-Wallis test, Mann-Whitney U-
test, Fisher's exact test
Result : Maternal toxicity:
mortality: 3/25 females at 450 mg/kg bw/day
No abortions or early deliveries (1 litter at 30 mg/kg bw was fully resorbed)
450 mg/kg bw:
decreased food consumption
stat. sign. reduction in periodic maternal body weight and weight gain
during dosing, maternal gestational weight gain reduced when corrected for
the weight of the gravid uterus and reduced maternal terminal bw, relative
but not absolute liver weight was increased
clin. signs of toxicity: hypoactivity, ataxia and tremors, prone position
audible respiration and perioral wetness
gestational parameters were unaffected by treatment except fetal body
weight per litter were reduced at 450 mg/kg bw.
fetal evaluations:
No significant changes in the incidence of any individual malformation,
malformation by category (external, visceral including craniofacial or
skeletal) or total malformations for any dose group.
450 mg/kg bw:
7 skeletal variations exhibited sign. different incidences relative to those in
the control groups:
incidence of cervical centrum 6 bilobed, reduced number of ossified caudal
segments, unossified sternebrae, reduced incidence of unossified cervical
centrum no. 7, poorly ossified parietal skull bone (30 mg/kg bw), reduced
incidence of some (1-4) proximal phalanges of the hind limb unossified
p-Cresol caused mild fetotoxicity at the 450 mg/kg, as seen
by reduced ossification in three skeletal districts. In
addition, fetal body weight was reduced at the 450 mg/kg dose
level. There was no treatment-related increased incidence of
malformations at any dosage.
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
06.02.2004 (169)
Species : rabbit
Sex : female
Strain : New Zealand white
Route of admin. : gavage
Exposure period : days 6 - 18 of gestation
Frequency of treatm. : daily
Duration of test : until gd 29
Doses : 0, 5, 50, 100 mg/kg bw in corn oil
Control group : yes, concurrent vehicle
NOAEL maternal tox. : = 5 mg/kg bw
NOAEL teratogen. : = 100 mg/kg bw
Result : see freetext ME
Method : other: following the TSCA Health Effects Test guidelines for Specific
Organ/Tissue Toxicity - Developmental Toxicity (EPA, 1984,1987)
Year : 1988
GLP : yes
Test substance : other TS: p-cresol, purity = 98.93%
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