m-Cresol - ipcs inchem

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OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 Study description suffers from deficiencies: no information about cytotoxicity and whether a metabolic activation system was used or not, only summary results given Flag : Critical study for SIDS endpoint 06.02.2004 (157) Type : Ames test System of testing : Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, TA1538 Test concentration : 0, 0.5, 5, 50, 500, 5000 ug/plate dissolved in DMSO, highest dose cytotoxic Cycotoxic concentr. : 5000 ug/plate Metabolic activation : with and without Result : negative Method : other: see freetext ME Year : 1975 GLP : no data Test substance : other TS: p-cresol, purity : 98 % Method : plate incorporation. method according to Ames, Mutat. Res. 31, 347 (1975), solv.: DMSO, S9-MIX: of Aroclor-pretreated rat liver as metabolic activation. system CONTROLS: as positive control:sodium azide,2-nitrofluorene, 9- aminoacridine,2-aminoanthracene, as solvent control: DMSO DATA EVALUATION: Significance level for positive dose-response effects were obtained with the Joncheere test STATISTICAL ANALYSIS: Joncheere test Remark : Positive controls were functional Reliability : (1) valid without restriction Flag : Critical study for SIDS endpoint 06.02.2004 (158) Type : Sister chromatid exchange assay System of testing : cultured male human fibroblasts Test concentration : 0, 0.008, 0.8, 4, 8 mM diluted in 95 % EtOH, 10, 30 mM diluted in MEM Cycotoxic concentr. : from 10 mM onwards Metabolic activation : without Result : negative Method : other: see freetext ME Year : 1984 GLP : no data Test substance : other TS: p-cresol, > 99% pure Method : p-Cresol was added to the cells and incubated, in triplicate, at 37 C for 2 hours. Following exposure, the cells were washed, reincubated in the absence of the test chemical for 48 hours, harvested and SCE frequency and cell-cycle kinetics analysed. SOLVENT: p-Cresol was dissolved in 95% ethanol at concentrations up to and including 8 mM and in Eagle's minimum essential medium (MEM) at concentrations above this. CONTROLS: 95% Ethanol and mitomycin C were used as negative and positive controls respectively. EVALUATION CRITERIA: positive if a dose-dependant significant incrase in SCE frequencies compared to control is observed STATISTICAL ANALYSIS: Dunnett's test Remark : p-Cresol did not induce significant increases over the control SCE frequencies. The positive control was functional. p-Cresol caused a small but statistically significant decrease in cell-cycle progression at 8 mM (864 mg/l) and above, indicative of a small cytotoxic response. Reliability : (2) valid with restrictions only tested in the absence of metabolic activation and no information on 272 UNEP PUBLICATIONS
OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 GLP Flag : Critical study for SIDS endpoint 06.02.2004 (159) Type : Ames test System of testing : Salmonella typhimurium TA98, TA100, TA1535, TA1537 Test concentration : no data Cycotoxic concentr. : Metabolic activation : with and without Result : negative Method : other: according to Ames, Mutation Res. 31, 347 (1975) Year : 1980 GLP : no data Test substance : other TS: p-cresol, not specified further Reliability : (4) not assignable documentation insufficient for assessment 06.02.2004 (160) Type : Unscheduled DNA synthesis System of testing : other: human lung fibroblast Test concentration : no data Cycotoxic concentr. : no data Metabolic activation : with Result : positive Method : other: no data reported Year : 1978 GLP : no data Test substance : other TS: p-cresol, not specified further Reliability : (4) not assignable secondary literature: description of the test suffers from deficiencies Flag : Critical study for SIDS endpoint 06.02.2004 (161) Type : other: DNA adduct formation System of testing : calf thymus DNA Test concentration : 100 uM Cycotoxic concentr. : no data Metabolic activation : with Result : positive Method : other: see freetext ME Year : 2001 GLP : no Test substance : other TS: p-cresol, highest analytical grade available Method : p-Cresol was activated with (1) PB-induced rat liver microsomal protein, (2) horseradish peroxidase and then incubated with calf-thymus DNA overnight at 37 degree Celcius and adducts were measured by P- postlabeling analysis . p-Cresol was oxidized with MnO2 to form a quinone methide and then incubated with calf-thymus DNA as described above and adducts were measured Result : In vitro activation of p-Cresol with (1) horseradish peroxidase produced six DNA adducts with a relative adduct level of 8.03 x 10(exp)-7 which were inhibited 65 and 95 % by addition of either 250 or 500 uM ascorbic acid to the incubation. (2) PB-induced rat liver microsomes resulted in the formation of a single UNEP PUBLICATIONS 273
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
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OECD SIDS m-CRESOL 3. ENVIRONMENTAL
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OECD SIDS m-CRESOL 4. ECOTOXICITY I
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OECD SIDS m-CRESOL 6. REFERENCES ID
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OECD SIDS p-CRESOL 1. GENERAL INFOR
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OECD SIDS m- / p-CRESOL MIXTURE 3.
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