m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL MIXTURE
5. TOXICITY ID: 15831-10-4
DATE: 24.05.2004
Type : other
Species : Drosophila melanogaster
Sex : no data
Strain : other: Berlin - Wild Type eggs
Route of admin. : other: see method
Exposure period : other: see method
Doses : other: see method
Result : negative
Method : other: Isolated ovaries of Berlin wild Typ Drosophila melanogaster were
treated with cresol (1:10^3) for 15 min and then implanted into a host. The
chromosomes of the descendants were examined.
Year : 1949
GLP : no
Test substance : other TS: no data
Result : no mutations were found.
Reliability : (4) not assignable
unusual test method
23.10.2002 (103)
5.7 CARCINOGENICITY
17.06.2002
17.06.2002
5.8.1 TOXICITY TO FERTILITY
Type : other: Reproductive Assessment by Continuous breeding (RACB)
Species : mouse
Sex : male/female
Strain : CD-1
Route of admin. : oral feed
Exposure period : 14 w
Frequency of treatm. : continuously in diet
Premating exposure period
Male : 7 d
Female : 7 d
Duration of test : 41 w
No. of generation : 2
studies
Doses : 0, 0.25, 1.0, 1.5 % (target dosage: 0, 375, 1500, 2250 mg/kg bw/day)
Control group : yes, concurrent no treatment
NOAEL parental : .25 %
other: NOAEL (Fertility : 1 %
F0, F1)
Method : other: NTP 2 generation continuous breeding protocol, see freetext ME
Year : 1990
GLP : yes
Test substance : other TS: m-/p-cresol (60%:40% mixture)
Method : NTP continuous breeding protocol:
Task 1:
dose-finding, see Chapter 5.4
Task 2:
reproduction and fertility study: 20 ps/group, 40 ps
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