m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL
marrow hypoplasia was found in rats after exposure to p-cresol at ≥ 3000 ppm (256 mg/kg bw/day),
with m/p-cresol at 15,000 ppm, and in mice after exposure to p-cresol and m/p-cresol at 30,000
ppm.
Increased colloid within thyroid follicles in female rats were observed with m/p-cresol only at ≥ 509
mg/kg bw/day, but the biological significance of this observation is uncertain.
Based on the data from the subacute and subchronic studies there is no evidence to suggest that a
significant increase in toxicity occurs with longer exposures
In a poorly documented neurotoxicity study in rats with m-cresol and p-cresol, convulsions were
seen only in the groups treated with ≥ 450 mg/kg bw/day. Hypoactivity, rapid labored respiration
and excessive salivation were observed sporadically at doses of ≥ 50 mg/kg bw/day. In spite of the
observed clinical signs, few significant changes were found in performance on neurobehavioural
test batteries, no brain weight changes were noted, and no gross or histopathological lesion in the
brain or other nervous tissues were found for any isomer (TRL 1986 as cited in IPCS 1995).
Results of repeated dose oral toxicity studies with m-cresol, p-cresol and m/p-cresol (60:40) are
summarized in the following tables:
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