m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
3. ENVIRONMENTAL FATE AND PATHWAYS ID: 108-39-4
DATE: 24.05.2004
It is a common observation that test substance adsorbes at the surface of
the algae. Due to the high surface / volume ratio a high BCF could be
obtained.
Test condition : 20-25 degrees C
Test substance : 14C-m-cresol
Reliability : (2) valid with restrictions
No standard test procedure, but in accordance with generally accepted
scientific standards and described in sufficient detail
12.05.2004 (26)
Species : other: Activated Sludge
Exposure period : 5 day(s) at °C
Concentration :
BCF : 1100
Elimination :
Method :
Year : 1985
GLP : no
Test substance : other TS: 14C-labelled m-cresol presumably > 98 % purity; no specific
activity given
Remark : Values of bioaccumulation factors range from 10 up to 42,800.
Esters and higher alcohols are placed in the intermediate range between
3,000 and 5,000. Sodium acetat with an accumulation factor of 29,100 is
remarkable. In this ranking m-Cresol belongs to the group of compounds
with low accumulation potential.
Correlation between accumulation factors and physico-chemical
parameters was not practicable.
Test substance : 14C-m-cresol
Reliability : (2) valid with restrictions
No standard test procedure, but in accordance with generally
accepted scientific standards and described in sufficient
detail.
12.05.2004 (26)
3.8 ADDITIONAL REMARKS
Memo : biodegradation under anaerobic conditions
Method : enrichment cultures prepared by addition of 3 g/l m-cresol
once per week
initial concentration 200-300 mg/l test substance
incubation at 37 degrees C in the dark
Result : 1st step: incorporation of CO2 giving
4-hydroxy-2-methylbenzoic acid
2nd step:
2a: dehydroxylation to 2 methylbenzoic acid (not further
metabolized) to a minor degree
2b: ring reduction, ring fission and beta-oxidation to
acetate. Ring reduction appeared to be the rate-limiting
step, because no subsequent intermediates accumulated
Test substance : 1. U-ring-14C m-cresol
2. methyl-14C m-cresol
Reliability : (2) valid with restrictions
No standard test procedure, but in accordance with generally accepted
scientific standards and described in sufficient detail
11.12.2002 (52)
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