m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
5.0 TOXICOKINETICS, METABOLISM AND DISTRIBUTION
In Vitro/in vivo : In vivo
Type : Distribution
Species : dog
Number of animals
Males :
Females :
Doses
Males :
Females :
Vehicle :
Route of administration : oral unspecified
Exposure time :
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
Deg. product :
Result : Following oral exposure cresols in the body initially concentrate in the
blood, liver, brain followed by more widespread distribution in the lungs,
kidneys and other unspecified organs (no further details given)
Reliability : (4) not assignable
secondary literature
25.10.2002 (106)
In Vitro/in vivo : In vivo
Type : Toxicokinetics
Species : rabbit
Number of animals
Males :
Females :
Doses
Males :
Females :
Vehicle : other: sodiumhydroxycarbonate
Route of administration : gavage
Exposure time :
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
Deg. product :
Method : other: see freetext ME
Year : 1949
GLP : no
Test substance : other TS: m-cresol, not specified further
Method : Approx. 200 mg/kg bw was administered to 10 rabbits (sex not mentioned)
as single dose as solution in bicarbonate by gavage. Urine was collected
over a period of 24-48 hours and the levels of free and conjugated cresol
was estimated by the method of Folin O. and Ciocalteu V., J. biol. Chem.
73, 627 (1927). Metabolites were identified with the method described in
118
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