m-Cresol - ipcs inchem

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OECD SIDS m- / p-CRESOL MIXTURE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 15831-10-4 DATE: 24.05.2004 3.7 BIOACCUMULATION Species : Leuciscus idus melanotus (Fish, fresh water) Exposure period : 3 day(s) at °C Concentration : .05 mg/l BCF : 20 Elimination : no data Method : other: measured Year : 1985 GLP : no Test substance : other TS: 14C-labelled m-cresol presumably > 98 % purity; no specific activity given Remark : Determination of radioactivity includes possible metabolized and/or incorporated intermediates The authors report BCF in different tables to be 17 or 20 Test condition : 5 fish (2-4 g) were exposed to m-cresol in a closed system and concentrations were determined by following radioactivity in fish and water; BCF values related to wet weight; 20-25 degrees C; pH 7; hardness 100 mg CaO/l Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail Flag : Critical study for SIDS endpoint 12.05.2004 (15) Species : other: Chlorella fusca (algae) Exposure period : 24 hour(s) at °C Concentration : .05 mg/l Elimination : no data Method : other: measured Year : 1985 GLP : no Test substance : other TS: 14C-labelled m-cresol presumably > 98 % purity; no specific activity given Remark : In this study BCF-values of 40 and 4,900 for algae are reported without explanation for the difference. It is a common observation that test substance adsorbes at the surface of the algae. Due to the high surface / volume ratio a high BCF could be obtained. Test condition : 20-25 degrees C Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 12.05.2004 (15) Species : other: Activated Sludge Exposure period : 5 day(s) at °C Concentration : BCF : 1100 Elimination : Method : other: measured Year : 1985 GLP : no Test substance : other TS: 14C-labelled m-cresol presumably > 98 % purity; no specific activity given 324 UNEP PUBLICATIONS
OECD SIDS m- / p-CRESOL MIXTURE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 15831-10-4 DATE: 24.05.2004 Remark : Values of bioaccumulation factors range from 10 up to 42,800. Esters and higher alcohols are placed in the intermediate range between 3,000 and 5,000. Sodium acetat with an accumulation factor of 29,100 is remarkable. In this ranking m-<strong>Cresol</strong> belongs to the group of compounds with low accumulation potential. Correlation between accumulation factors and physico-chemical parameters was not practicable. Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail. 12.05.2004 (15) 3.8 ADDITIONAL REMARKS Memo : biodegradation under anaerobic conditions Method : enrichment cultures prepared by addition of 3 g/l m-cresol once per week initial concentration 200-300 mg/l test substance incubation at 37 degrees C in the dark Result : 1st step: incorporation of CO2 giving 4-hydroxy-2-methylbenzoic acid 2nd step: 2a: dehydroxylation to 2 methylbenzoic acid (not further metabolized) to a minor degree 2b: ring reduction, ring fission and beta-oxidation to acetate. Ring reduction appeared to be the rate-limiting step, because no subsequent intermediates accumulated Test substance : 1. U-ring-14C m-cresol 2. methyl-14C m-cresol Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 11.12.2002 (41) UNEP PUBLICATIONS 325
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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