m-Cresol - ipcs inchem

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OECD SIDS m- / p-CRESOL MIXTURE 5. TOXICITY ID: 15831-10-4 DATE: 24.05.2004 5.0 TOXICOKINETICS, METABOLISM AND DISTRIBUTION In Vitro/in vivo : In vivo Type : Toxicokinetics Species : other Number of animals Males : Females : Doses Males : Females : Vehicle : Result : At physiological pH, the conjugated metabolite of phenolic compounds are ionized to a greater extent than the parent compound, which reduces renal reabsorption and increases elimination with the urine. In addition to urinary excretion, cresols are excreted in the bile, butr the most part undergoes enterohepatic circulation. there are known species differences in the specific conjugation reactions of cresol isomers. The relative amounts of gluucuronide and sulfate conjugates therefore differ between species and also vary with dose. Reliability : (2) valid with restrictions basic information 09.01.2003 (95) (96) (97) (98) 5.1.1 ACUTE ORAL TOXICITY 5.1.2 ACUTE INHALATION TOXICITY 17.06.2002 5.1.3 ACUTE DERMAL TOXICITY 17.06.2002 5.1.4 ACUTE TOXICITY, OTHER ROUTES 17.06.2002 5.2.1 SKIN IRRITATION Species : rabbit Concentration : undiluted Exposure : Semiocclusive Exposure time : 4 hour(s) 352 UNEP PUBLICATIONS
OECD SIDS m- / p-CRESOL MIXTURE 5. TOXICITY ID: 15831-10-4 DATE: 24.05.2004 Number of animals : 3 Vehicle : other: none PDII : Result : corrosive Classification : Method : other: in accordance with classification of corrosive hazards, Fed. Reg. Vol. 37, No.57, §173.240 - D.O.T., see freetext ME Year : 1972 GLP : no Test substance : other TS: no data on purity and composition of mixture Method : 0.5 ml of undiluted sample was applied to the clipped, intact skin of 3 New Zealand white male and female rabbits under 1 inch square patch, 2 single layers thick. The patches were held in place with adhesive tape in such a manner that evaporation was retarded, but not prevented, for the 4 hour exposure period. The data were scored according to the method of Draize, Woodward and Calvery (J. of Pharm. Exp. therapeutics Vol. 82, December, 1944) Result : 4-Hours: necrosis, severe edema 24 hours: eschar formation (corrosive) Scab sloughed off in 14 - 17 days showing injury in depth Reliability : (2) valid with restrictions only a summary description: individual animal data not given, no purity of the TS given Flag : Critical study for SIDS endpoint 16.12.2002 (99) 5.2.2 EYE IRRITATION 5.3 SENSITIZATION Type : other Species : guinea pig Number of animals : Vehicle : other: acetone Result : not sensitizing Classification : Method : other: a 7,5 % solution of a mixture of m- and p-cresol in acetone was repeatedly supplied to the skin of guinea pig Year : 1998 GLP : no data Test substance : other TS: mixture of m- and p-cresol, not specified further Reliability : (2) valid with restrictions limited documentation Flag : Critical study for SIDS endpoint 05.02.2004 (100) 04.12.2002 5.4 REPEATED DOSE TOXICITY Type : Sub-chronic Species : rat UNEP PUBLICATIONS 353
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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m-Cresol - ipcs inchem

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