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m-Cresol - ipcs inchem

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OECD SIDS<br />

m-CRESOL<br />

4. ECOTOXICITY ID: 108-39-4<br />

DATE: 24.05.2004<br />

4.1 ACUTE/PROLONGED TOXICITY TO FISH<br />

Type : flow through<br />

Species : Oncorhynchus mykiss (Fish, fresh water)<br />

Exposure period : 96 hour(s)<br />

Unit : mg/l<br />

LC50 : 8.9<br />

Limit test :<br />

Analytical monitoring : yes<br />

Method : other: US EPA, Methods for acute toxicity tests with fish,<br />

macroinvertebrates, and amphibians. Nat. Environm. Res. Center, Corvallis<br />

(1974)<br />

Year : 1980<br />

GLP : no data<br />

Test substance : other TS: m-cresol, no purity reported<br />

Method : Mean length/mean weight of fish: 7.9 cm/6.0 g<br />

Result : sublethal effects: hyperactivity, rapid operculation,<br />

sensitive to disturbance and gathering at the surface<br />

Test condition : DILUTION WATER<br />

- Source: well water<br />

- Hardness: 707.3 mg CaCO3/l<br />

- Conductance: 1212.3 µmhos/cm at 25 degrees C<br />

TEST SYSTEM<br />

- Concentrations: 1:2 dilution series<br />

- Number of replicates: 2<br />

- fish per replicate: 10<br />

- Test temperature: 14 degrees C<br />

- Dissolved oxygen: 6.5 mg/l (84.5% of saturation)<br />

- pH: 8.1<br />

- Photoperiod: 16 h light, 8 h dark<br />

Reliability : (1) valid without restriction<br />

Test procedure comparable to standard method and in<br />

accordance with generally accepted scientific standards;<br />

detailed documentation of test procedure and test conditions<br />

Flag : Critical study for SIDS endpoint<br />

07.05.2004 (53)<br />

Type : flow through<br />

Species : Pimephales promelas (Fish, fresh water)<br />

Exposure period : 96 hour(s)<br />

Unit : mg/l<br />

LC50 : 55.9<br />

Limit test :<br />

Analytical monitoring : yes<br />

Method : other: US EPA, Methods for acute toxicity tests with fish,<br />

macroinvertebrates, and amphibians. Nat. Environm. Res. Center, Corvallis<br />

(1974)<br />

Year : 1980<br />

GLP : no data<br />

Test substance : other TS: m-cresol, no purity reported<br />

Method : Mean length/mean weight of fish: 4.9 cm/1.6 g<br />

Result : sublethal effects: loss of equilibrium, erratic swiming and<br />

twitching at a test substance concentration of 49.8 mg/l<br />

Test condition : DILUTION WATER<br />

- Source: well water<br />

- Hardness: 707.3 mg CaCO3/l<br />

- Conductance: 1212.3 µmhos/cm at 25 degrees C<br />

UNEP PUBLICATIONS 91

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