m-Cresol - ipcs inchem

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OECD SIDS p-CRESOL 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 106-44-5 DATE: 24.05.2004 Method : Determination of absorption rate across gills Analytical measurements in inspired and expired water, calculation of gill uptake efficiency Result : About 23% of the TS were taken up via the gills (value taken from a graphics) Test condition : 1 fish per experiment Reliability : (3) invalid Only 1 fish tested, no BCF determined 07.05.2004 (75) 3.8 ADDITIONAL REMARKS Memo : biodegradation under three different anaerobic (denitrifying, sulfidogenic, methanogenic) conditions Method : biodegradation was studied with acclimated and unacclimated sedimet samples from a freshwater pond Result : the proposed reaction pathway is: p-Cresol > p-hydroxybenzyl alcohol > p- hydroxybenzaldehyde > p-hydroxybenzoate for all three conditions. Under methanogenic conditions, p-hydroxybenzoate reacts to benzoate with subsequent ring fission. Under denitrifying and sulfidogenic conditions, p- hydroxybenzoate did not react to benzoate, immediate ring fission is postulated. Test substance : other TS: p-cresol, no purity reported (Aldrich, Milwaukee, WI) Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 12.12.2002 (70) Memo : biodegradation under anaerobic (sulfate-reducing) conditions Method : acclimated aquifer slurries (alluvial sand) amended with either Na2MoO4, bromoethanesulfonic acid, or Na2SO4 HPLC measurements Result : the proposed reaction pathway is: p-Cresol > p-hydroxybenzyl alcohol > p- hydroxybenzaldehyde > p-hydroxybenzoate Test substance : other TS: p-cresol, no purity reported (obtained from Aldrich Chemical Co.) Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 12.12.2002 (68) Memo : biodegradation under anaerobic (sulfate-reducing) conditions Method : Ring-14C-labeled p-cresol incubated with bacteria enriched from the sulfate-reducing portion of an anoxic aquifer. Periodical analysis of the enrichment by HPLC. Result : the proposed reaction pathway is: p-Cresol > p-hydroxybenzyl alcohol > p- hydroxybenzaldehyde > p-hydroxybenzoic acid. The pathway diverges after p-hydroxybenzoic acid to form benzoic acid and phenol. Test substance : Ring-14C-labeled p-cresol Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 12.12.2002 (76) 220 UNEP PUBLICATIONS
OECD SIDS p-CRESOL 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 106-44-5 DATE: 24.05.2004 Memo : biodegradation pathway with activated sludge Result : p-cresol is first hydroxylated to 4-methylcatechol and cleaved through meta-cleavage pathway. Test substance : p-cresol, no purity reported in abstract Reliability : (4) not assignable Publication in Japanese 12.05.2004 (77) UNEP PUBLICATIONS 221
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m- / p-CRESOL MIXTURE I U
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OECD SIDS m- / p-CRESOL MIXTURE 1.
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