m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL MIXTURE
5. TOXICITY ID: 15831-10-4
DATE: 24.05.2004
as the only parameter affected (adjusted live pup weight)
was decreased if either sex was dosed.
F1-pups: 1.5 %-group:
birth weights decreased by 5 %, decreased preweaning growth
by 26 % and postweaning survival decreased by 39 %
clinical signs: reduced size, dehydratation, lethargy, rough
coat
F1-adults:
no effect on reproductive performance:
1.0 and 1.5%-group, male:
decreased bw, decreased reproductive organ weights
(prostate, seminal vesicles, testes), but no effects on
sperm parameters or histology, increased relative liver and
kidney weights
1 and 1.5 %-group, female:
terminal bw reduced
0.25-, 1.0-, and 1.5 %-group, female:
ovarian weight reduced, kidney- and liver-weights increased
no effect of treatment on oestrous cyclicity and ovarian or
liver and kidney histology
NOAEL(F0, F1, general toxicity): 0.25 %, based on
differences in bw and organ weights to the concurrent
controls.
Reproductive competence of F0, F1-generation was not
affected by treatment.
NOAEL(fertility, F0, F1): 1 %
F0-generation 1.5 % - group: decreased adjusted live pups
weights, decreased number of live pups per litter and
increase of the cumulative days to the fifth litter
F1 generation 1.5 % -group: live pup weights and adjusted
live pup weights reduced.
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
05.02.2004 (102)
5.8.2 DEVELOPMENTAL TOXICITY/TERATOGENICITY
19.06.2002
5.8.3 TOXICITY TO REPRODUCTION, OTHER STUDIES
Type : other:
In vitro/in vivo : In vivo
Species : rat
Sex : male/female
Strain : other: F344/N
Route of admin. : oral feed
Exposure period : 13 w
Frequency of treatm. : daily
Duration of test : 13 w
Doses : 0, 1880, 7500, 30000 ppm
Control group : yes, concurrent no treatment
Result : See freetext RS
366
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