m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
no information about strain used, exposure time : 1 hr, only one
concentration
Flag : Critical study for SIDS endpoint
06.02.2004 (116)
Type : LC50
Value : = 58 mg/m³
Species : rat
Strain : no data
Sex : no data
Number of animals :
Vehicle : no data
Doses : no data
Exposure time :
Method : other: aerosol-exposure; no further data
Year : 1975
GLP :
Test substance : other TS: m-cresol, not specified further
Remark : the mean lethal concentration of m-cresol was measured. The original data
are not published and no further experimental details are availabel from the
citing literature
Result : Clinical signs of toxicity included irritation of mucous membranes,
neuromuscular excitiation and convulosions; hematuria at very high
concentrations (no further information)
Reliability : (2) valid with restrictions
Secondary citation from peer-reviewed data source
Flag : Critical study for SIDS endpoint
06.02.2004 (122)
Type : other: inhalation of mist
Value :
Species : rat
Strain :
Sex : no data
Number of animals : 6
Vehicle :
Doses :
Exposure time : 8 hour(s)
Method : other: mist was generated by holding the compound in a bath of 170
degree Celsius, observation period: 14 d
Year : 1949
GLP : no
Test substance : other TS: no data on purity
Result : all rats survived the exposure period; only 1/6 failed to
gain weight during the observation period
Reliability : (4) not assignable
documentation suffers from significant deficiencies
18.09.2002 (120)
Type : other: inhalation of saturated vapour
Value :
Species : rat
Strain :
Sex : no data
Number of animals : 6
Vehicle : other: air
Doses :
Exposure time : 8 hour(s)
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