m-Cresol - ipcs inchem

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OECD SIDS m-CRESOL 5. TOXICITY ID: 108-39-4 DATE: 24.05.2004 25 randomly selected F1 pups/sex/dose were gavaged with the appropriate concentration of m-cresol for 11 weeks and then bred to produce F2 litters (dosing was continued throughout mating, gestation and lactation) F2 offspring was sacrificed at weaning. reproductive indices: mating indices for males and females, fertility indices for males and females, gestational index, live birth index, 4-day survival index 7-day survival index, 21-day survival index, lactation index Necropsy and pathology: all F0 and F1 parental rats in all groups were subjected to a complete necropsy ; 25 male and 25 female adults from the controls and from the high dose groups were subjected to histopathology examination: pituitary, vagina, uterus, ovaries. testes, epididymides, seminal vesicles, prostate and other tissues with gross lesions identified as potentially treatment related; any of thze above organs or tissues showing gross alterations were also evaluated microscopically in other dose groups A complete gross necropsy and histopathologic examination were conducted for any parental rat dying on test Gross necropsy included examination of the external surfaces, all orificwes, cranila cavity, carcass, external and cut surfaces of the brain and spinal cord, the thoracic,abdominal and pelvic cavities and their viscera, cervical tissues and organs a gross internal examination on any F1 and F2 pup appearing abnormal or dying on testA complete gross necropsy and histopathologic examinations were conducted for any animals dying on test. statistical methods: Levene's test,ANOVA, t-test corrected by Bonferroni method, Kruskal- Wallis test, Mann Whitney U-test, Fishers exact test Result : F0: pre-breed dosing period: 450 mg/kg: f,m: significant reduced body weight, signs of toxicity: hypoactivity, ataxia, twitches, tremors, prostration, unkempt appearance(males), urine stains, audible respiration perinasal encrustration and perioral wetness; mortality: 7/25 m, 5/25 f; 175 mg/kg: sacrifice due to trauma 1/25 m F0: breed period: 450 mg/kg: maternal gestat. and lactat. bw sign. reduced, mortality: 450 mg/kg:2/20 f; 175 mg/kg: 1/25 f; reproductive parameters including gestational length were unaffected by treatment F1: litter size, sex ratio, litter viability, pup survival were unaffected by treatment; 450 mg/kg: reduced female pup bw F1 pre-breed period: slightly reduced bw in m (450, 175,30 mg/kg) and in f (450,30 mg/kg); signs of toxicity: 450 mg/kg bw: hypoactivity, ataxia twitches, tremors prostration urine stains, audible respiration and perioral wetness (also at 175 mg/kg females); mortality: 450 mg/kg 3 m and 4 f; F1 breed period: 450, 175, 30 mg/kg: reduced bw in m; maternal gestational and lactational bw reduced in 450 mg/kg f; mortality during gestation: 1 f each at control, 30, 175 mg/kg and 3 f at 450 mg/kg, mortality during lactation: 3 f at 450 mg/kg Reproductive parameters including gestational parameters were unaffected by treatment F2: litter size and sex ratio unaffected; F2 pup lactational 150 UNEP PUBLICATIONS
OECD SIDS m-CRESOL 5. TOXICITY ID: 108-39-4 DATE: 24.05.2004 index was reduced at 450 mg/kg 450 mg/kg: pup bw and pup bw gain was reduced and pup deaths increased. Pathology: all groups: there were no treatment related gross lesions or histologic lesions in F0, F1 and F2 rats which survived to scheduled sacrifice. dead prior to schedule: F0,F1 m: lesions in brain , thymic regions, lungs, decrease in number of sperm in epididymides, atrophied seminal vesicles and coagulation glands, epididymitis; F0,F1 f: lesions in the brain, lungs NOAEL (fertility): 450 mg/kg bw The exact A/D ratio cannot be calculated. But it can be assumed that the A/D ratio would be less than 1 (
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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