m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
GLP : no data
Test substance : other TS: no data on purity
Reliability : (4) not assignable
documentation insufficient for assessment
18.09.2002 (127)
Species : rabbit
Concentration :
Exposure :
Exposure time :
Number of animals :
Vehicle :
PDII :
Result :
Classification :
Method : other: see remarks
Year :
GLP :
Test substance :
Remark : Paper discs were soaked with 30 ul of m-cresol (dilutions
1:1 to 1:64) and kept secured on the shaved dorsal skin for
30 min. Then 6 ml/kg bw of a 1 % solution of Evan's blue
were injected i.v.. After 10 min the rabbits were
sacrificed, the dorsal skin was exfoliated, spread on glass
plates, and lighted from behind. The paper discs were
removed and the sites of application were examined.
The lowest concentration causing dye exsudation was found at
a dilution of 1:16 (6.25 %).
The lowest concentration causing corrosion was found at a
dilution of 1:2 (50 %).
Reliability : (4) not assignable
unusual test method
18.09.2002 (128)
5.2.2 EYE IRRITATION
Species : rabbit
Concentration : undiluted
Dose : .1 ml
Exposure time : unspecified
Comment : no data
Number of animals : 6
Vehicle :
Result : highly irritating
Classification :
Method : other: undiluted 0.1 ml, time of reading: 24, 48 and 72 hours
Year : 1969
GLP : no data
Test substance : other TS: m-cresol, M.P.: 11-12 C; B.P.: 202.8 C
Remark : after 24 hrs: cornea, iris, conjunctivae: 87.3 (mean score) mean score for
cornea: 60, mean score for iris: 10, mean score for conjunctivae: 18)
after 48 hrs: cornea, iris, conjunctivae: 87.3 (mean score)
mean score for cornea: 60, mean score for iris: 10, mean score for
conjunctivae: 18)
after 72 hrs: cornea, iris, conjunctivae: 87.3 (mean score)
mean score for cornea: 60, mean score for iris: 10, mean score for
conjunctivae: 18)
UNEP PUBLICATIONS 133