m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
Deg. product :
Remark : p- Cresol undergoes enterohepatic circulation when administered orally to
dogs and rabbits.
Reliability : (2) valid with restrictions
16.01.2003 (127) (128)
In Vitro/in vivo : In vivo
Type : Toxicokinetics
Species : other
Number of animals
Males :
Females :
Doses
Males :
Females :
Vehicle :
Result : At physiological pH, the conjugated metabolites of phenolic compounds are
ionized to a greatedr extent than the parent compound, which reduces the
renal reabsorption and increases the elemination with the urine.
In addition to urinary excretion, cresols are excreted in the bile, but the
most part undergoes enterohepatic circulation. There are known species
differences in the specific conjugation reactions of cresol isomers. The
relative amounts of glucuronide and sulfate conjugates therefore differ
between species and also vary with the dose.
Reliability : (2) valid with restrictions
basic information
Flag : Critical study for SIDS endpoint
09.01.2003 (127) (129) (130) (131)
In Vitro/in vivo : In vivo
Type : Excretion
Species : human
Number of animals
Males : 22
Females : 10
Doses
Males :
Females :
Vehicle :
Method :
Year :
GLP :
Test substance : other TS: p-cresol, not specified further
Result : Daily excretion of p-Cresol was measured in the 24-hrs urine samples from
ten healthy females and 22 healthy males. Mean urinary p-Cresol levels
were 58.9 +/- 43.7 mg/d for males and 45.7+/-23.5 mg/d for females
Reliability : (2) valid with restrictions
Flag : Critical study for SIDS endpoint
06.02.2004 (132)
In Vitro/in vivo : In vivo
Type : Excretion
Species : human
Number of animals
Males : 6
Females : 4
Doses
Males :
252
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