m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
Remark : Dose selection was based on the results of a range-finding study.
14 mated females/group, 28 control females, all females were weighed on
gd 0, 6, 12, 18, 24 and 29, food consumption was measured throughout
gestation, all females were examined daily for clinical signs, for mortality
and morbidity
sacrifice on gd 29:
does were evaluated for body weight, liver and gravid uterine weight,
number of corpora lutea and number and status of implantation sites (i.e.
resorptions, dead fetuses, live fetuses)
live fetuses were dissected from uterus, counted and weighed, examined
for external malformations and variations, and for visceral malformaltions
and variations, and for soft tissue craniofacial malformations
statistical analysis:
Levene's test, ANOVA, pooled t-test, Kruskal-Wallis test, Mann-Whitney U-
test, Fisher's exact test
Result : mortality: 100 mg/kg bw: 5/14; 50 mg/kg bw: 2/14;
all were pregnant
1 control female aborted and one each at 5.0 and 50 mg/kg bw was
removed due to dosing error
gestational weights and weight changes were not stat. significant different
among groups for periodic body weights or weight changes.
50, 100 mg/kg bw: clinical signs included hypoactivity, gasping, cyanosis,
laboured rapid and audible respiration and ocular discharge
food consumption: no significant differences among groups for any time
period measured; no treatment related gross lesions at necropsy of does
maternal organ weights:
no significant difference among the groups: terminal bw., gravid uterine
weight, corrected bw. or weight change, absolute and relative liver weight
gestational parameters:
no significant difference for number of ovarian corpora lutea, number of
implantations sites including total, nonviable (early or late resorptions or
dead fetuses) or viable percent live fetuses per litter or fetal body weight
per litter; sex ratio was significantly increased (more males) at 50 mg/kg bw
but not at 100 mg/kg bw (considered due to biological variabilty)
fetal evaluation:
No significant differences among groups for any individual malformations,
malformations by category or total malformations; no treatment-related
significant differences for any individual external variations, variations by
category or total variations.
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
06.02.2004 (170)
5.8.3 TOXICITY TO REPRODUCTION, OTHER STUDIES
Type : other
In vitro/in vivo : In vivo
Species : mouse
Sex : male/female
Strain : B6C3F1
Route of admin. : oral feed
Exposure period : 28 d
Frequency of treatm. : continuously in diet
Duration of test : 28 d
Doses : 0, 300, 1000, 3000, 10000, 30000 ppm
Control group : yes, concurrent no treatment
Result : See freetxt RS
Method : other: the reproductive organs were examined as part of the 28-day study,
see chapter 5.4
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