m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
Result : The positive controls were functional.
p-Cresol was evaluated as non-mutagenic in the mouse lymphoma cell
system
Reliability : (2) valid with restrictions
No differentiation between large and small colony mutants;
statistical evaluation not mentioned
Flag : Critical study for SIDS endpoint
06.02.2004 (155)
Type : DNA damage and repair assay
System of testing : human lymphocytes
Test concentration : 5 - 25 uM
Cycotoxic concentr. : no data
Metabolic activation : without
Result : positive
Method : other: see freetext ME
Year : 1986
GLP : no data
Test substance : other TS: p-cresol, not specified further
Method : p-Cresol was tested for its ability to inhibit
semiconservative DNA synthesis. Initially, DNA repair was
induced by irradiation and, in these cells, semiconservative
DNA synthesis was blocked by treatment with hydroxyurea. In both
studies, cells were treated with
radiolabelled thymidine for 2 hours and incorporation of
thymidine into the cells was measured.
no solvent mentioned, no negative or positive control, no statistical
evaluation reported
Result : p-Cresol inhibited both UV-induced DNA repair synthesis and
semiconservative DNA synthesis as seen by a reduction in
radiolabelled thymidine incorporation. It was unclear from
the report if this inhibition was seen at all concentrations
tested but at the top dose, 21% inhibition of DNA repair
synthesis and 25% inhibition of semiconservative DNA
synthesis was found.
Reliability : (2) valid with restrictions
no solvent mentioned, no negative or positive control, no information on
cytotoxicity, no statistical evaluation reported
Flag : Critical study for SIDS endpoint
06.02.2004 (156)
Type : Sister chromatid exchange assay
System of testing : human lymohocytes
Test concentration : 0 - 0.5 mM
Cycotoxic concentr. : no data
Metabolic activation : no data
Result : negative
Method : other: see freetext ME
Year : 1986
GLP : no data
Test substance : other TS: p-cresol, 99.9% purity
Method : Lymphocyte fraction from healthy donors were grown in Medium 199 with
Earles salts. After 24 hrs of cultur p-Cresol diluted in DMSO was added for
88-90 hrs.
positive control: Styrene-7,8-oxide.
statistical method: Linear regression analysis
Remark : Results of the positive control or solvent control in comparison to p-cresol
are not given
Reliability : (2) valid with restrictions
UNEP PUBLICATIONS 271