m-Cresol - ipcs inchem

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OECD SIDS m- / p-CRESOL MIXTURE 4. ECOTOXICITY ID: 15831-10-4 DATE: 24.05.2004 1 0 0 - - 0.1 100 100 86.5 77.1 Reliability : (3) invalid Methodological deficiencies 12.05.2004 (89) 4.6.3 TOXICITY TO SOIL DWELLING ORGANISMS 4.6.4 TOX. TO OTHER NON MAMM. TERR. SPECIES Species : other avian: Agelaius phoeniceus (red-winged blackbird) Endpoint : mortality Exposure period : Unit : mg/kg bw LD50 oral : 113 Method : Year : 1983 GLP : no data Test substance : other TS: m-cresol Test condition : birds pre-conditioned to captivity for 2 to 6 weeks dosed by gavage with solution in propylene glycol or by pellets resp. gelatin capsules Reliability : (2) valid with restrictions Unsuitable test system 11.02.2003 (90) 4.7 BIOLOGICAL EFFECTS MONITORING 4.8 BIOTRANSFORMATION AND KINETICS Remark : In aquarium water of 12 species of freshwater fish 48 h after exposure to 3-15 mg/l m-cresol, cresyl sulphate (55-64% of 14C recovered) or m-hydroxybenzoic acid (0-39 %) were found In bile of 11 species, cresyl glucuronide (63-74 %), cresyl sulphate (8-20 %) and m-hydrobenzoic acid (5-12 %) were found Unchanged m-cresol detected in both aquarium water and bile Test substance : m-[U-14C]cresol Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 17.10.2001 (91) 4.9 ADDITIONAL REMARKS 350 Memo : Sea urchin test Remark : Strongylocentrotus droebachiensis (sea urchin): static test, 5 degrees C Determined effect endpoints: death, pathology, inhibition of UNEP PUBLICATIONS
OECD SIDS m- / p-CRESOL MIXTURE 4. ECOTOXICITY ID: 15831-10-4 DATE: 24.05.2004 cleavage and differentiation, pigment defects EC50 (96 h): ca. 30 mg/l Test substance : other TS: m-cresol, purity > 98 % as determined by GC (obtained from Merck) Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 12.05.2004 (46) Memo : Tree neoplasms Remark : m-cresol (1.5 % v/v) showed a toxicity rating from 3-4 (0 = no injury, 5 = complete kill within 14 d) in tomato crown gall tumors incited by Agrobacterium tumefaciens. Test substance : other TS: m-cresol, no purity reported Reliability : (3) invalid Unsuitable test system 12.05.2004 (92) Memo : Hela cell screening Remark : In a rapid-cell culture assay with HeLa cells, m-cresol (4x10-5 to 4x10-3 M, 4 h incubation) showed a concentration-dependent inhibition of 3H labeled thymidine incorporation into DNA incubation 4 h Test substance : other TS: m-cresol, no purity reported Reliability : (3) invalid Unsuitable test system 12.05.2004 (93) (94) Memo : Mollusc Remark : Teredo diegensis (Mollusca): LC50 (72 h): 100 mg/l Test substance : other TS: m-cresol, no purity reported Reliability : (4) not assignable Reference not available 12.05.2004 (54) UNEP PUBLICATIONS 351
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
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OECD SIDS m-CRESOL 3. ENVIRONMENTAL
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OECD SIDS m- / p-CRESOL MIXTURE I U
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OECD SIDS m- / p-CRESOL MIXTURE 1.
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m-Cresol - ipcs inchem

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