m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL MIXTURE
5. TOXICITY ID: 15831-10-4
DATE: 24.05.2004
Number of animals : 3
Vehicle : other: none
PDII :
Result : corrosive
Classification :
Method : other: in accordance with classification of corrosive hazards, Fed. Reg. Vol.
37, No.57, §173.240 - D.O.T., see freetext ME
Year : 1972
GLP : no
Test substance : other TS: no data on purity and composition of mixture
Method : 0.5 ml of undiluted sample was applied to the clipped,
intact skin of 3 New Zealand white male and female rabbits
under 1 inch square patch, 2 single layers thick. The
patches were held in place with adhesive tape in such a
manner that evaporation was retarded, but not prevented, for
the 4 hour exposure period.
The data were scored according to the method of Draize,
Woodward and Calvery (J. of Pharm. Exp. therapeutics Vol.
82, December, 1944)
Result : 4-Hours: necrosis, severe edema
24 hours: eschar formation (corrosive)
Scab sloughed off in 14 - 17 days showing injury in depth
Reliability : (2) valid with restrictions
only a summary description: individual animal data not
given, no purity of the TS given
Flag : Critical study for SIDS endpoint
16.12.2002 (99)
5.2.2 EYE IRRITATION
5.3 SENSITIZATION
Type : other
Species : guinea pig
Number of animals :
Vehicle : other: acetone
Result : not sensitizing
Classification :
Method : other: a 7,5 % solution of a mixture of m- and p-cresol in acetone was
repeatedly supplied to the skin of guinea pig
Year : 1998
GLP : no data
Test substance : other TS: mixture of m- and p-cresol, not specified further
Reliability : (2) valid with restrictions
limited documentation
Flag : Critical study for SIDS endpoint
05.02.2004 (100)
04.12.2002
5.4 REPEATED DOSE TOXICITY
Type : Sub-chronic
Species : rat
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