m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL MIXTURE
5. TOXICITY ID: 15831-10-4
DATE: 24.05.2004
Reliability : (1) valid without restriction
12.11.2002 (101)
Type : other
In vitro/in vivo : In vivo
Species : mouse
Sex : male/female
Strain : B6C3F1
Route of admin. : oral feed
Exposure period : 28 d
Frequency of treatm. : continuously in feed
Duration of test : 28 d
Doses : 0, 300, 1000, 3000, 10000, 30000 ppm (m: 0, 50, 161, 471, 1490, 4530
mg/kg bw; f: 0, 65, 200, 604, 1880, 4730 mg/kg bw)
Control group : yes, concurrent no treatment
Result : m, 30000 ppm: increased testes weight without histopathologic correlate; f,
30000 ppm: atrophy of ovaries and uterus
Method : other: see chapter 5.4.
Year : 1991
GLP : yes
Test substance : other TS: m/p-cresol (60%:40% mixture)
Reliability : (1) valid without restriction
05.09.2002 (101)
5.9 SPECIFIC INVESTIGATIONS
5.10 EXPOSURE EXPERIENCE
Remark : Case Report: Muenchhausen's Syndrome with multiple skin
ulcers caused by cresol is the diagnosis resulting from the
findings of a 25 years old female nursing student.
Reliability : (4) not assignable
16.01.2003 (104)
Remark : It is reported that mortality from bladder cancer was
increased among molders in the foundry industry. The author
suggest that cresols might act as tumour promotor.
Reliability : (4) not assignable
16.01.2003 (105)
Remark : It is reported that 2 patients with chronic exposure to
cresol or creosote developed multifocal transitional
carcinoma of the bladder with muscle invasion.
Reliability : (2) valid with restrictions
16.01.2003 (106)
Remark : Case Report: A 52 year old man attempted to commit suicide
by ingesting approximately 100 ml of penetrating oil, a
petroleum distillate containing 85% kerosine, 12% mixed
cresols, 2% surfactant and 1% artificial colour. He revealed
a massive intravascular Heinz-body hemolytic anemia
associated with the presence of bizarre-looking
erythrocytes. He was treated successfully.
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