m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
weights at terminal and recovery necropsies: liver, kidneys, lungs, spleen,
adrenal glands, thymus, testes, ovaries, organ weight to terminal body
weight ratios were calculated.
Microscopic examination on respiratory tract (target tissue) of the first 5
rats/sex/group
statistical methods:
one way analyses of variance (ANOVA)
Result : observed concentration: 27 ug/l, achieved pulmonary dose level: 690 ug/kg
bw
no animal died during the study,
no treatment related clinical signs; incidental observations in all treatment
groups including control groupswere salivation, diarrhea, wet inguinal fur,
red material around nose and eyes, alopecia, lesions and red material
around nose seen sporadically and in low frequencies during recovery
period.
Body weights, body weight gain, hematology, blood chemistry were not
statistically different from control group.
terminal and recovery sacrifices:
no statistically differences in organ weights when compared to controls and
no test-article related gross or histopathologic lesions. Observed minor
inflammatory or degenerative changes observed in peribronchial,
perivascular and subserosal regions were evaluated as incidental findings
in rodent inhalation studies
Reliability : (4) not assignable
study suffers from deficiencies: only 1 dose used, solvent (aquous glycerol)
was not the control, detailed data of the results were not presented, result
description did not differ between phenol and m-cresol
06.02.2004 (129) (129)
Type : Sub-acute
Species : rat
Sex : male
Strain : no data
Route of admin. : oral feed
Exposure period : 28 d
Frequency of treatm. : daily
Post exposure period : no
Doses : 0, 20, 150, 500 mg/kg diet (approx. 0, 1.86, 13.95 or 45.8 mg/kg bw/d)
Control group : yes, concurrent no treatment
NOAEL : ca. 45.8 mg/kg bw
Method : other: 10 rats/group, TS was prepared as a 2.0 % corn oil solution and
blended with the diet; diets were prepared fresh weekly. Control rats
received basal diets containing 2 % corn oil, necropsy of all animals
Year : 1969
GLP : no data
Test substance : other TS: M.P.:11-12 C; B.P.: 202.8 C
Result : No deaths occurred during the study and no untoward
behavioural reactions were noted.
At necropsy, no significant gross lesions were noted among
the test animals, when compared to the control animals.
Reliability : (4) not assignable
documentation insufficient for assessment
18.09.2002 (116)
Type : Sub-acute
Species : rat
Sex : male/female
Strain : other: F344/N
Route of admin. : oral feed
Exposure period : 28 days
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