m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
Toxic behaviour :
Deg. product :
Method : other: see freetext ME
Year : 1949
GLP : No
Test substance : other TS: p-cresol, not specified further
Method : 100-200 mg/kg bw was administered to rabbits (number and sex not
mentioned) as single dose as solutions in bicarbonateby gavage. Urine
was collected over a period of 24 -48 hours and the levels of free and
conjugated cresol was estimated by the method of Folin O. and Ciocalteu
V., J. biol. Chem. 73, 627 (1927). Metabolites were identified with the
method described in Bray et al., Biochem J. 41, 212 (1947) and 43, 561
(1948)
Result : absorption and excretion:
Within 24 hours 65 % of the p-Cresol dose was excreted in the urine
indicating that at least this amount was absorbed through the
gastrointestinal tract and urinary excretion was the main route of
elimination.
metabolism:
The principal metabolic pathway was conjugation with glucuronic and
sulphuric acids: 15% of the dose were discovered as ethereal sulphate and
61% of the dose as ethereal glucuronide and 2% of the dose as free cresol.
About 7 % of the dose was free hydroxybenzoic acid, about 3 % of the
dose was conjugated hydroxybenzoic acid; conjugated dihydroxytoluene
was only discovered in traces as 3,4-dihydroxytoluene.
Reliability : (2) valid with restrictions
no information on sex and number of rabbits used, no information on
distribution in the tissue
Flag : Critical study for SIDS endpoint
06.02.2004 (122) (123)
In Vitro/in vivo : In vivo
Type : Distribution
Species : Dog
Number of animals
Males :
Females :
Doses
Males :
Females :
Vehicle :
Route of administration : oral unspecified
Exposure time :
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
Deg. product :
Method : other: no data
Year : 1971
GLP : No
Test substance : other TS: p-cresol, not specified further
Result : Following oral exposure cresols in the body concentrate in the blood, liver,
and brain initially, but soon become more widespread and appear in the
lungs, kidneys and other unspecified organs (no further details given)
Reliability : (4) not assignable
250
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