m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
secondary literature
Flag : Critical study for SIDS endpoint
06.02.2004 (124)
In Vitro/in vivo : In vivo
Type : Absorption
Species : Rat
Number of animals
Males :
Females :
Doses
Males :
Females : 10 mg/m3
Vehicle : other: air
Route of administration : inhalation
Exposure time : 4 hour(s)
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
Deg. product :
Method : other: female rats,concentr.: 10 mg/m3, 4 hrs daily for 100 d up to 4
months
Year : 1975
GLP : no data
Test substance : other TS: p-cresol, not specified further
Remark : female rats were exposed to 10 mg/m3 p-cresol 4 hours per
day, daily for 100 d up to 4 months. p-Cresol reached a
concentration of 20.7ug/g lung tissue; the neutral red
sorption on day 3 resp d 39 was 150 % resp. 212 % of the
control value as a marker for cytotoxicity. Full recovery
did not occur.
Reliability : (2) valid with restrictions
information on absorption via lung, but study description suffer from
deficiencies
Flag : Critical study for SIDS endpoint
06.02.2004 (125) (126)
In Vitro/in vivo : In vivo
Type : Toxicokinetics
Species : other: dogs and rabbits
Number of animals
Males :
Females :
Doses
Males :
Females :
Vehicle :
Route of administration : oral unspecified
Exposure time :
Product type guidance :
Decision on results on acute tox. tests :
Adverse effects on prolonged exposure :
Half-lives : 1 st :
2 nd :
3 rd :
Toxic behaviour :
UNEP PUBLICATIONS 251