m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL MIXTURE
5. TOXICITY ID: 15831-10-4
DATE: 24.05.2004
6/10[1.0]) and
uterus atrophy in females: 0/10, 0/10, 0/10, 0/10,
3/10[1.0], 7/10[1.7].
Evaluation of other reproductive organs (see also chapter
5.8.3) revealed no significant findings in males but
lengthened oestrus cycle in females significant from 7500
ppm
Haematology, clinical chemistry, urinalysis data (only sign.
changes, incidences not given):
haematocrit (male, female, increase, 30000 ppm, d5; female,
decrease, d43 from 15000 ppm), haemoglobin (increase, male,
female, d5, 30000 ppm), red blood cell count (increase,
male, female, d5, d21, 30000 ppm), mean cell volume
(decrease, female, 30000 ppm at d5, from 15000 ppm d21 to
d90), mean cell haemoglobin (decrease, female, 30000 ppm,
d21, d90), mean cell haemoglobin concentration (increase,
female, from 15000 ppm d5, d43), platelet count (increase,
male, 15000 ppm, d21; 30000 ppm, d21, d43; female, d21 from
7500 ppm, d43 at 15000 ppm), reticulocytes (decrease,
female, from 15000 ppm d5), white blood cell count
(increase, male, d21, 15000 ppm), lymphocytes (male,
increase, d21, 15000 ppm), monocytes (male, increased from
1880 ppm at d5; female, decrease d90 at 30000 ppm),
urea nitrogen (male, increase, from 15000 ppm at d5,
decrease from 1880 ppm at d43 and from 15000 ppm at d90;
female, increase at d 5 from 3750 ppm, decrease at d43 from
3750 ppm),
alanine aminotransferase (increase, d5: male, 30000 ppm,
female from 15000 ppm), alkaline phosphatase (male,
decrease, d21 from 15000 ppm, d43, 7500 ppm, 30000 ppm),
5'-nucleotidase (decrease, male, d5 30000 ppm, d21 from 3750
ppm, d43 from 7500 ppm, d90 30000 ppm: female, d5 from 15000
ppm, d21, d43 from 7500 ppm, d90 from 3750 ppm), sorbitol
dehydrogenase (male, increase d5 from 7500 ppm), bile acids
(increase, male, d5 from 15000 ppm and at 30000 ppm, d21,
d43, and d90 at 3750 ppm and 30000 ppm; female, d21 from
1880 ppm, d43 from 15000 ppm, d90 30000 ppm),
urine aspartate aminotransferase (male, increase, d43, d90,
from 7500 ppm; female, decrease, d41, from 3750 ppm), urine
N-acetyl-ß-glucose aminidase (increase, male, d41, from 7500
ppm, d90 from 15000 ppm; female, d90 30000 ppm), urine
volume (decrease, male, d41 30000 ppm, d90 from 7500 ppm),
specific gravity (increase, male, d41,d90, from 7500 ppm)
local toxicity: NOAEL(male, female): < 1880 ppm
systemic toxicty: NOAEL(male, female): 3750 ppm
Reliability : (1) valid without restriction
Flag : Critical study for SIDS endpoint
16.12.2002 (101)
Type : Sub-chronic
Species : mouse
Sex : male/female
Strain : B6C3F1
Route of admin. : oral feed
Exposure period : 13 w
Frequency of treatm. : continuously in feed
Post exposure period : no
Doses : 0, 625, 1250, 2500, 5000, 10000 ppm (see RM)
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