m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Year : 1949
GLP : no
Test substance : other TS: purity no data
Remark : at the dosage level used the rats developed tremor within a
few minutes, deaths occurred within a few hours
Reliability : (4) not assignable
Documentation insufficient for assessment
18.09.2002 (120)
Type : LD50
Value : = 828 mg/kg bw
Species : mouse
Strain :
Sex : no data
Number of animals :
Vehicle : other: oil
Doses :
Method : other: 10 % oil solution
Year : 1974
GLP : no data
Test substance : other TS: purity not mentioned
Reliability : (4) not assignable
secondary citation
17.12.2002 (112) (119)
Type : other: dose selection study for MNT
Value :
Species : mouse
Strain :
Sex : male/female
Number of animals : 6
Vehicle : other: corn oil
Doses : 400, 800, 1200, 1600, 2000 mg/kg bw (dose volumes: 5 ml/kg bw)
Method : other: 3 mice/sex and dose received one dose by gavage:
400,800,1200,1600,2000 mg/kg bw, post dose observation for 2 d for toxic
effects and mortality
Year : 1989
GLP : yes
Test substance : other TS: Purity: 99.8 %
Remark : the study was performed in order to select doses for a mouse in vivo bone
marrow cytogenetic assay (see chapter 5.6)
Result : 2000 mg/kg:immediately after dosing all mice showed
convulsions, experienced difficulties in breathing, and were
extremely lethargic; mortality: 6/6
1600, 1200 mg/kg: all mice showed convulsions 2-4 min. after
dosing, experienced breathing difficulties and lethargy;
mortality: 1600 mg/kg: 6/6; 1200 mg/kg: male 1/3, female
2/3, all other rats showed signs of recovery
800 mg/kg: all mice showed convulsions 4-5 min. after dosing
with difficulty in breathing and lethargy, no rat died; all
showed signs of recovery after 2 d
400 mg/kg: all mice apparently healthy
Reliability : (2) valid with restrictions
only 2 days post-exposure observation;
preliminary dose range finding study
10.01.2003 (121)
Type : other: LD
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