m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
Year : 1977
GLP : no data
Test substance : other TS: p-cresol, not specified further
Method : TS applied to the clipped backs or flanks of the rabbits (no data whether
the test substance was moistened). The material was covered by a surgical
gauze two layers thick, gauze patches were held in place with strips of
Elastoplast tape for 4 hours. After 4 hrs the patches were carefully
removed and the test areas were evaluated for visible tissue destruction.
evaluation criterias:
When visible tissue destruction occurred in at least 2/6 rabbits, the test
materials were classified as corrosive (no further details given).
Reliability : (2) valid with restrictions
description of the method suffers from deficiencies
Flag : Critical study for SIDS endpoint
06.02.2004 (140)
Species : rabbit
Concentration : undiluted
Exposure : no data
Exposure time : no data
Number of animals : 6
Vehicle :
PDII :
Result : highly irritating
Classification :
Method : other: 0.5 ml undiluted TS was applied to the intact and abraded skin, time
of observation: 24 and 72 hrs.
Year : 1969
GLP : no data
Test substance : other TS: p-cresol, M.P.: 36 C; B.P.: 202 C
Result : intact skin: erythema: 24 hr: Score 4 in 6/6
72 hr: Score 4 in 6/6
edema: 24 hr: Score 4 in 6/6
72 hr: Score 4 in 6/6
abraded skin: erythema: 24 hr: Score 4 in 6/6
72 hr: Score 4 in 6/6
edema: 24 hr: Score 4 in 6/6
72 hr: Score 4 in 6/6
no tissue destruction and /or necrosis reported
Summary: irritation score: 8.00/8.00
Reliability : (2) valid with restrictions
limited documentation; no information on exposure time
Flag : Critical study for SIDS endpoint
06.02.2004 (139)
5.2.2 EYE IRRITATION
260
Species :
Concentration :
Dose :
Exposure time :
Comment :
Number of animals :
Vehicle :
Result : highly irritating
Classification :
Method : other
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