m-Cresol - ipcs inchem

OECD SIDS
p-CRESOL
5. TOXICITY ID: 106-44-5
DATE: 24.05.2004
NEGATIVE CONTROL: 0.35 ml sunflower oil (4 intact and 5
hepatectomized male mice, bone marrow cells, alveolar macrophages, liver
cells)
POSITIVE CONTROL: 5 mg cyclophosphamide/kg bw (2 intact male mice,
bone marrow cells, alveolar macrophages).
STATISTICAL ANALYSIS: One way analysis of variance; Dunnett's test for
comparison
Result : p-Cresol did not induce significant increases in SCE
frequencies in any of the cell types examined: bone marrow cells, alveolar
macrophages, liver cells.
The dose tested was overtly toxic to the mice, causing lethargy,
piloerection and lacrimation.
The positive control was functional.
Reliability : (2) valid with restrictions
only one dose tested, no information on GLP
Flag : Critical study for SIDS endpoint
06.02.2004 (159)
5.7 CARCINOGENICITY
276
Species : mouse
Sex : female
Strain : other: Sutter
Route of admin. : dermal
Exposure period : 12 weeks (I) or 20 weeks (II)
Frequency of treatm. : twice weekly
Post exposure period : no
Doses : 20 (I) or 5.7 % (II) solutions in benzene
Result :
Control group : yes, concurrent vehicle
Method : other: tumor promotion test (see freetext RM)
Year : 1959
GLP : no
Test substance : other TS: p-cresol, not specified further
Remark : Groups of 20-29 Sutter strain mice:
I. method: initiator: single dermal appl. of 0.3 % 9,10-dimethyl-1,2-
benzanthracene (DMBA) in acetone; p-cresol (in benzene) was applied as
promotor to the back of each mouse
I. result: 20/28 mice (12/12 benzene control animals); survived and
in 35 % (0 % in control animals); skin papillomas were found; no
carcinomas were detected
II. method: initiator: single dermal appl. of 0.3 % DMBA in
benzene; promotor: p-cresol was applied to the back of each mouse
II.result: 14/20 mice (18/20 benzene control animals) survived and in
29 % (0 % in control animals) skin papillomas were found; no carcinomas
were detected
Result : p-Cresol was evaluated as promotor
Reliability : (2) valid with restrictions
no data on the purity, benzene a known carcinogen as solvent, high
mortality rate; no information on skin irritation effects
Flag : Critical study for SIDS endpoint
06.02.2004 (165)
Species : hamster
Sex : male
Strain : other: Syrian Golden
Route of admin. : oral feed
Exposure period : 20 weeks
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