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OECD SIDS m- / p-CRESOL MIXTURE 4. ECOTOXICITY ID: 15831-10-4 DATE: 24.05.2004 12.05.2004 (61) 4.5.1 CHRONIC TOXICITY TO FISH 4.5.2 CHRONIC TOXICITY TO AQUATIC INVERTEBRATES 4.6.1 TOXICITY TO SEDIMENT DWELLING ORGANISMS 4.6.2 TOXICITY TO TERRESTRIAL PLANTS Species : other terrestrial plant: Lactuca sativa Ravel R2 Endpoint : growth Exposure period : 14 day(s) Unit : mg/kg soil dw EC50 : 96 Method : OECD Guide-line 208 "Terrestrial Plants, Growth Test" Year : 1993 GLP : no data Test substance : other TS: m-cresol, purity >= 95 % Method : analytical monitoring at start and end of test Result : EC50 based on nominal concentration; for most of the examined phenols (including m-cresol) applied concentrations dropped to < 20% of the nominal values Reliability : (2) valid with restrictions Guideline study; applied test concentrations not stable during the test period Flag : Critical study for SIDS endpoint 12.05.2004 (88) Species : other terrestrial plant: Lactuca sativa Ravel R2 Endpoint : growth Exposure period : 16 day(s) Unit : mg/l EC50 : 50 Method : Year : 1993 GLP : no data Test substance : other TS: m-cresol, purity >= 95 % Method : semistatic test in nutrient solution, renewed 3 times/week nutrient solution as described in Steiner, A.A.: Soilless culture. Proceedings, Sixth Colloqium of the International Potash Institute, Florence, Italy, 324-341 (1968); analytical monitoring of TS at start and end of exposure and before renewal of test solution Result : EC50 based on nominal concentration; TS concentration before renewal of test solution > 50% of initial concentration Reliability : (3) invalid unsuitable test system 11.02.2003 (88) Species : Raphanus sativus (Dicotyledon) Endpoint : other: germination and growth rate 348 UNEP PUBLICATIONS
OECD SIDS m- / p-CRESOL MIXTURE 4. ECOTOXICITY ID: 15831-10-4 DATE: 24.05.2004 Exposure period : 4 day(s) Unit : g/l Method : Year : 1989 GLP : no Test substance : other TS: m-cresol, special grade purity (obtained from Wako Pure Chemicals Industries, Ltd.) Method : seeds exposed to test compounds dissolved in distilled water 24 degrees C, 10h light, 14 h dark 3 replicates of 20 seeds Result : Concentr. Germination rate% Growth rate % g/l 1 day 4 days Radicle Hypocotyl 10 0 0 - - 1 0 5.3 2.0 - 0.1 82.6 95.0 80.8 104.7 Reliability : (3) invalid Methodological deficiencies 12.05.2004 (89) Species : Brassica rapa (Dicotyledon) Endpoint : other: germination and growth rate Exposure period : 4 day(s) Unit : g/l Method : Year : 1989 GLP : no Test substance : other TS: m-cresol, special grade purity (obtained from Wako Pure Chemicals Industries, Ltd.) Method : seeds exposed to test compounds dissolved in distilled water 24 degrees C, 10h light, 14 h dark 3 replicates of 20 seeds Result : Concentr. Germination rate% Growth rate % g/l 1 day 4 days Radicle Hypocotyl 10 0 0 - - 1 0 0 - - 0.1 85.8 91.5 54.9 72.8 Reliability : (3) invalid Methodological deficiencies 12.05.2004 (89) Species : Brassica campestris var. chinensis (Dicotyledon) Endpoint : other: germination and growth rate Exposure period : 4 day(s) Unit : g/l Method : Year : 1989 GLP : no Test substance : other TS: m-cresol, special grade purity (obtained from Wako Pure Chemicals Industries, Ltd.) Method : seeds exposed to test compounds dissolved in distilled water 24 degrees C, 10h light, 14 h dark 3 replicates of 20 seeds Result : Concentr. Germination rate% Growth rate % g/l 1 day 4 days Radicle Hypocotyl 10 0 0 - - UNEP PUBLICATIONS 349
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
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