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OECD SIDS m-CRESOL 5. TOXICITY ID: 108-39-4 DATE: 24.05.2004 gland, mammary gland, thymus, thyroid (with parathyroid), lungs (with mainstem bronchi), trachea, liver, urinary bladder, testes, prostate, ovaries, corpus and cervix uteri, eye, pituitary gland, lymph node, spinal cord, heart, aorta, siatic nerve, pancreas, oesophagus, kidneys, small and large intestine, adrenals, stomach STATISTICAL ANALYSIS One-way Analysis of Variance tests with Dunnett's t-test Result : MORTALITY/CLINICAL OBSERVATIONS: 450 mg/kg: one high dose male was found dead on day 5 (cause not evident), signs of intoxication: 450 mg/kg bw, male, female: lethargy, tremors, hunched posture, rough hair coats post dosing BODY WEIGHT was sign reduced (p
OECD SIDS m-CRESOL 5. TOXICITY ID: 108-39-4 DATE: 24.05.2004 temperature: 72° +/-3° F, humidity: 50 % +/-15 %, Fluorescent light: 12 hrs/day, room air changes : 10-12 changes/hr TYPE AND FREQUENCY OF OBSERVATION: observed twice daily, body weight taken initially, weekly, and at termination, feed consumption by cage recorded twice weekly NECROPSY AND HISTOLOGIC EXAMINATION: necropsy and tissue collection performed for all animals. A complete histopathologic examination was conducted on all control animals, all animals in the highest dose group with at least 60 % survivors at study termination, and all aninmals in higher dose groups inclusive of early deaths. The following organs and/or tissues were included in complete histopathological examinations, as well as any tissue masses, gross lesions, and associated regional lymph nodes: adrenals, aorta, bone (sternebrae, femur, or vertebrae, including marrow), brain, bronchi, clitoral gland, epididymis, oesophagus, gallbladder, heart, kidney, large intestines (caecum, colon, rectum), liver, lungs, lymph nodes (mesenteric), mammary glands, nasal cavity and turbinates, oral cavity, ovaries, pancreas, parathyroids, pharynx, pituirary, preputial gland, prostate, salivary glands, scrotal sac, seminal vesicles, skin, small intestine (duodenum, ileum, jejunum), spleen, stomach, testes, thymus, thyroid, tongue, trachea, tunica vaginalis, urinary bladder, uterus and Zymbal's glands. Target organs and gross lesions were examined at lower doses until a no-observed chemical effect was determined. Target organs included the following: uterus and ovaries and mammary gland. Organ weights recorded for brain, liver, right kidney, thymus, heart, and lungs of all animals, and the right testis of all males. STATISTICAL METHODS: nonparametric multiple comparison test of Dunn and Shirley, Jonckheere's test Remark : mean compound consumption (mg/kg bw/day): males females 0 ppm 0 0 300 ppm 53 66 1000 ppm 193 210 3000 ppm 521 651 10000 ppm 1730 2080 30000 ppm 4710 4940 Result : mortality: 0 ppm: 1/5 male; 10000 ppm: 1/5 females; 300000 ppm: 2/5 males, 2/5 females; Signs of toxicty: at 30000 ppm: male, female; hunched posture, rough hair coat, thin appearance, lethargy and tremor,hypothermia (only females), at 10000 ppm: males and females, hunched posture, rough hair coat, females only: laboured respiration lethaty, sunken eyes final mean body weight reduced at 30000 ppm in males (p
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m- / p-CRESOL MIXTURE I U
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