m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Route of admin. : i.v.
Exposure time :
Method : other: intravenous injection to 1 rabbit per dose of an 0.5 % aqueous
solution, 4 doses, time until death was recorded
Year : 1944
GLP : no data
Test substance : other TS: purity no data
Remark : hours until death: 120 and 180 mg/kg: no death; 280 mg/kg:
15 hours; 420 mg/kg: 7 hours
Reliability : (4) not assignable
unusual application route
18.09.2002 (118)
Type : other: LD
Value : = 150 mg/kg bw
Species : dog
Strain :
Sex : no data
Number of animals :
Vehicle : other: no data
Doses :
Route of admin. : i.v.
Exposure time :
Method : other: no data
Year :
GLP : no
Test substance : other TS: no data
Reliability : (4) not assignable
unusual application route
18.09.2002 (124)
5.2.1 SKIN IRRITATION
Species : rabbit
Concentration : .5 other: ml
Exposure : Semiocclusive
Exposure time : 4 hour(s)
Number of animals : 6
Vehicle :
PDII :
Result : corrosive
Classification :
Method : other: see freetext ME
Year : 1977
GLP : no data
Test substance : other TS: m-cresol, not specified further
Method : TS applied to the clipped backs or flanks of the rabbits. The material was
covered by a surgical gauze two layers thick, gauze patches were held in
place with strips of Elastoplast tape for 4 hours. After 4 hrs the patches
were carefully removed and the test areas were evaluated for visible tissue
destruction.
evaluation criterias:
When visible tissue destruction occurred in at least 2/6 rabbits, the test
materials were classified as corrosive (no further details given).
Reliability : (2) valid with restrictions
Limited documentation
Flag : Critical study for SIDS endpoint
UNEP PUBLICATIONS 131