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m-Cresol - ipcs inchem

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OECD SIDS<br />

m- / p-CRESOL MIXTURE<br />

4. ECOTOXICITY ID: 15831-10-4<br />

DATE: 24.05.2004<br />

12.05.2004 (76)<br />

Type : aquatic<br />

Species : Tetrahymena pyriformis (Protozoa)<br />

Exposure period : 24 hour(s)<br />

Unit : mg/l<br />

LC100 : 375<br />

Analytical monitoring : no<br />

Method :<br />

Year : 1978<br />

GLP : no<br />

Test substance : other TS: m-cresol, no purity reported<br />

Test condition : 28 degrees C<br />

Reliability : (2) valid with restrictions<br />

No standard test procedure, but in accordance with generally<br />

accepted scientific standards and described in sufficient<br />

detail<br />

12.05.2004 (77)<br />

Type : aquatic<br />

Species : Uronema parduzci (Protozoa)<br />

Exposure period : 20 hour(s)<br />

Unit : mg/l<br />

TT : 62<br />

Analytical monitoring : no<br />

Method : other: cell multiplication inhibition test<br />

Year : 1980<br />

GLP : no<br />

Test substance : other TS: m-cresol, no purity reported<br />

Remark : TT = Toxicity threshold; determined at 5 % effect compared<br />

to control<br />

Test condition : 25 degrees C; initial pH 6.9<br />

Reliability : (2) valid with restrictions<br />

No standard test procedure, but in accordance with generally<br />

accepted scientific standards and described in sufficient<br />

detail<br />

12.05.2004 (78)<br />

Type : aquatic<br />

Species : Photobacterium phosphoreum (Bacteria)<br />

Exposure period : 5 minute(s)<br />

Unit : mg/l<br />

EC50 : 11<br />

Analytical monitoring : no<br />

Method : other: Microtox assay<br />

Year : 1983<br />

GLP : no data<br />

Test substance : other TS: m-cresol, no purity reported<br />

Remark : effect: reduction of bioluminescence<br />

Secondary literature. Not enough information supplied for<br />

assessment. Although the author suggests that Microtox may<br />

lack reproductibility due to variations in bacterial cell<br />

suspensions, no information is supplied on the maintenance<br />

of the lyophilized bacteria, their age, duration of<br />

reconstitution and other important parameters.<br />

Reliability : (3) invalid<br />

Unsuitable test system. Organisms are of marine origin.<br />

Method is not appropriate for the hazard assessment of<br />

UNEP PUBLICATIONS 343

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