m-Cresol - ipcs inchem

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OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 No. of generation : 2 studies Doses : 0, 30, 175, 450 mg/kg bw Control group : yes, concurrent vehicle NOAEL parental : ca. 30 mg/kg bw other: NOAEL (fertility) : ca. 450 mg/kg bw Result : see freetext RS Method : EPA OPP 83-4 Year : 1989 GLP : yes Test substance : other TS: p-cresol, 98.93% pure Remark : 25 rats/sex/dose (F0) were administered p-cresol in corn oil. Exposure began 10 weeks prior to breeding and continued in the females throughout mating, gestation and lactation. 25 randomly selected F1 pups/sex/dose were gavaged with the appropriate concentration of p-cresol for 11 weeks and then bred to produce F2 litters (dosing was continued throughout mating, gestation and lactation). The F2 offspring were sacrificed at weaning. Reproductive Indices: mating indices for males and females, fertility indices for male and females, gestational index, live birth index, 4-day survival index, 7-day survival index, 14-day survival index, 21-day survival index, lactation index Necropsy and pathology: all F0 and F1 parental rats in all groups were subjected to a complete necropsy ; 25 male and 25 female adults from the controls and from the high dose groups were subjected to histopathology examination: pituitary, vagina, uterus, ovaries. testes, epididymides, seminal vesicles, prostate and other tissues with gross lesions identified as potentially treatment related; any of thze above organs or tissues showing gross alterations were also evaluated microscopically in other dose groups A complete gross necropsy and histopathologic examination were conducted for any parental rat dying on test Gross necropsy included examination of the external surfaces, all orificwes, cranila cavity, carcass, external and cut surfaces of the brain and spinal cord, the thoracic,abdominal and pelvic cavities and their viscera, cervical tissues and organs a gross internal examination on any F1 and F2 pup appearing abnormal or dying on test Statistical methods: Levene's test for equal variances, analysis of variance (ANOVA), t-test, Kruskal-Wallis test, Mann-Whitney U test Fisher's exact test Result : Mortality: 8/28 males and 5/25 females at 450 mg/kg bw; 1/25 females at 30 mg/kg bw Clinical signs of toxicity occurred in F0 and F1 males and females at 450 mg/kg bw/day and included hypoactivity, ataxia, twitches, tremors, prostration, urine stains, audible respiration, perinasal encrustation (not in F0 males), and perioral wetness occurred at >= 175 mg/kg bw. body weight: F0 adult males, sign reduced (p
OECD SIDS p-CRESOL 5. TOXICITY ID: 106-44-5 DATE: 24.05.2004 gestational weight gain not significantly different from control group, lactational body weight sign. reduced (p
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
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OECD SIDS m-CRESOL 3. ENVIRONMENTAL
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