m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
GLP : yes
Test substance : other TS: m-cresol, purity > 99 %
Result : m-cresol did not produce significant increases in the number of
transformed foci, cytotoxicty: 62 nl/ml
Reliability : (2) valid with restrictions
non-validated test system
Flag : Critical study for SIDS endpoint
06.02.2004 (153)
Species : other: in vitro cell transformation assay
Sex :
Strain : other: Syrian Hamster embryo (SHE) cells
Route of admin. :
Exposure period :
Frequency of treatm. :
Post exposure period :
Doses :
Result : positive
Control group :
Method : other: no details reported
Year : 1987
GLP : no data
Test substance : other TS: no data on purity
Remark : abstract only
Result : m-cresol induced cell transformation
Reliability : (4) not assignable
abstract
documentation insufficient for assessment
17.12.2002 (154)
5.8.1 TOXICITY TO FERTILITY
Type : Two generation study
Species : rat
Sex : male/female
Strain : Sprague-Dawley
Route of admin. : gavage
Exposure period : 27 w
Frequency of treatm. : once/d, 7 d/w
Premating exposure period
Male : 10 w
Female : 10 w
Duration of test : 29 w
No. of generation :
studies
Doses : 0, 30, 175 or 450 mg/kg bw/d in corn oil
Control group : yes, concurrent vehicle
NOAEL parental : 30 mg/kg bw
NOAEL F1 offspring : ca. 175 mg/kg bw
Method : other: TSCA Health Effects Test Guideline for specific organ/tissue toxicity
- Reproduction/Fertility effects (EPA, 1983), see also freetext ME
Year : 1989
GLP : yes
Test substance : other TS: m-cresol, purity: 99.4 %
Method : 25 rats/sex/dose (F0) were administered m-Cresol in corn oil. Exposure
began 10 weeks prior to breeding and continued in the females throughout
mating, gestation and lactation.
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