m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL MIXTURE
3. ENVIRONMENTAL FATE AND PATHWAYS ID: 15831-10-4
DATE: 24.05.2004
Remark : Values of bioaccumulation factors range from 10 up to
42,800.
Esters and higher alcohols are placed in the intermediate
range between 3,000 and 5,000. Sodium acetat with an
accumulation factor of 29,100 is remarkable. In this ranking
m-Cresol belongs to the group of compounds with low
accumulation potential.
Correlation between accumulation factors and
physico-chemical parameters was not practicable.
Reliability : (2) valid with restrictions
No standard test procedure, but in accordance with generally
accepted scientific standards and described in sufficient
detail.
12.05.2004 (15)
3.8 ADDITIONAL REMARKS
Memo : biodegradation under anaerobic conditions
Method : enrichment cultures prepared by addition of 3 g/l m-cresol
once per week
initial concentration 200-300 mg/l test substance
incubation at 37 degrees C in the dark
Result : 1st step: incorporation of CO2 giving
4-hydroxy-2-methylbenzoic acid
2nd step:
2a: dehydroxylation to 2 methylbenzoic acid (not further
metabolized) to a minor degree
2b: ring reduction, ring fission and beta-oxidation to
acetate. Ring reduction appeared to be the rate-limiting
step, because no subsequent intermediates accumulated
Test substance : 1. U-ring-14C m-cresol
2. methyl-14C m-cresol
Reliability : (2) valid with restrictions
No standard test procedure, but in accordance with generally
accepted scientific standards and described in sufficient
detail
11.12.2002 (41)
UNEP PUBLICATIONS 325