m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL
Toxicity of m - and p-cresol in Short-term Tests:
Species
Exposure Effects [mg/l]
period
m-Cresol
p-Cresol
Pimephales promelas
96 h LC50 = 55.9 (e) LC50 = 28.6 (e)
Oncorhynchus mykiss 96 h LC50 = 8.9 (e) LC50 = 7.9 (e)
96 h LC50 = 8.6 (n) LC50 = 7.4 (n)
Leuciscus idus 48 h LC50 = 17 (n) LC50 = 11 (n)
Salmo trutta 96 h LC50 = 8.4 (n) LC50 = 4.4 (n)
Salvelinus fontinalis 96 h LC50 = 7.6 (n) LC50 = 5.8 (n)
Daphnia magna 24 h EC50 =19.2 (n) EC50 =12.4 (n)
Daphnia pulicaria 48 h EC50 > 99.5 (e) EC50 = 22.7 (e)
Chlorella pyrenoidosa 72 h EC50 = 50 - 250 (n) EC50 = 100 - 250 (n)
(n): nominal concentration
(e): effective concentration
Effect values obtained from tests on both m- and p-cresol indicate a similar toxicity of both isomers,
with p-cresol being slightly more toxic.
For long-term tests the toxicity cannot be compared directly, as no test performed with both isomers
are available. However, from the similarity in acute toxicity testing, it can be expected that the longterm
toxicity of both isomers is similar as well.
For the isomeric mixture m/p-cresol no ecotoxicity data are available. However, it is expected that
the toxicity of the isomeric mixture is covered by the data for m- and p-cresol.
Available Toxicity Data (Human Health)
The available data indicate a very similar pattern of toxicity of m-cresol, p-cresol and of the m/pcresol
mixtures:
The following data were identified:
Substance m-Cresol p-Cresol m/p-Cresol mixtures
Cas-No. 108-39-4 106-44-5
Acute toxicity
oral
dermal
inhalation
√/+
√/+
√/+
√/+
√/+
√/+
Irritation
skin
eye
√/+
√/+
√/+
√/+
√/+
Sensitization √/- √/- √/-
Repeated dose toxicity √/+ √/+ √/+
Genetic toxicity
in vitro
in vivo
√/+
√/+
Carcinogenicity X X
√/+
√/+
√/+
√/+
Effect on fertility
Developmental toxicity
√/+
√/+
√/+
√/+
√/+
√/+
Adequate data available
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