m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
GLP : no
Test substance : other TS: no data on purity
Remark : marginal effects
Reliability : (4) not assignable
documentation insufficient for assessment
20.09.2002 (143)
Type : Mouse lymphoma assay
System of testing : L 5178 Y (TK +/-) cells
Test concentration : with and without S9-mix: 52.0, 78.0, 104, 156, 260, 312, 416, 520 ug/ml in
DMSO
Cycotoxic concentr. : with and without S9-mix: 520 ug/ml;
Metabolic activation : with and without
Result : negative
Method : other: similar to OECD Guideline 476, No differentiation between large and
small colonies, see also freetext ME
Year : 1988
GLP : yes
Test substance : other TS: m-cresol, purity: 99.8 %
Method : S9-MIX of rat liver was used as metabolic activation system
SOLVENT: DMSO
CONTROL: DMSO and ethylmethane sulfonate, 3-methylcholantrene
served as negative and positive cotrol, respectively
EVALUATION CRITERIA: a solitive response was indicated by a > two-fold
increase of mutant frequency over the concurrent background frequencies
Result : m-cresol was evaluated as nonmutagenic in the mouse lymphoma cell
system.
The positive controls were functional
Reliability : (2) valid with restrictions
no differentiation between small and large colonies, statistical evaluation
not mentioned
Flag : Critical study for SIDS endpoint
06.02.2004 (144)
Type : Cytogenetic assay
System of testing : Allium cepa
Test concentration : 0, 0.015, 0.02 and 0.025 % in destilled water
Cycotoxic concentr. : no data
Metabolic activation : no data
Result : positive
Method : other: treatment period: 0: 3 hrs; 0.015 24 hrs; 0.02: 5 hrs; 0.025: 5 hrs
Year : 1965
GLP : no
Test substance : other TS: no data on purity
Reliability : (4) not assignable
documentation insufficient for assessment
20.09.2002 (145)
Type : Ames test
System of testing : Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538
Test concentration : 0, 0.5, 5, 50, 500, 5000 ug/plate dissolved in DMSO
Cycotoxic concentr. : 5000 ug/plate
Metabolic activation : with and without
Result : negative
Method : other: see freetext ME
Year : 1982
GLP : no data
Test substance : other TS: m-cresol, purity: 98 %
144
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