m-Cresol - ipcs inchem

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OECD SIDS m- / p-CRESOL MIXTURE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 15831-10-4 DATE: 24.05.2004 Test condition : screening optimized for mechanistic study m-cresol concentration: 200, 400 or 1000 mg/l incubation for 6 w at 37 degrees C Reliability : (4) not assignable No standard test procedure, but in accordance with generally accepted scientific standards; not relevant for purpose of HPV program 12.05.2004 (32) Type : anaerobic Inoculum : other: anaerobic sludge, adapted Concentration : 300 mg/l related to Test substance related to Deg. product : yes Method : other: see test condition Year : 1986 GLP : no Test substance : other TS: m-cresol, no purity reported (Aldrich chemicals) (methyl 14Clabelled from Pathfinder Lab.) Deg. products : 74-82-8 200-812-7 methane Result : Degradation: ca. 100 % after 9 days Most of the methyl carbon of m-cresol (87 %) was converted to CH4. Test condition : preincubation for 2-3 months incubation for 20 d at 37 degrees C Test substance : 14C-methyl labeled Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 12.05.2004 (33) Type : anaerobic Inoculum : anaerobic sludge Concentration : 50 mg/l related to DOC (Dissolved Organic Carbon) related to Deg. product : yes Method : other: measured Year : 1982 GLP : no Test substance : other TS: m-cresol, purity > 95 % Deg. products : 74-82-8 200-812-7 methane Method : - Sludge from 2 municipal plants - Methane production monitored - HPLC to monitor disappearance of substrate Result : mineralization (related to theoretical methane and CO2 production) was 92% after 4 weeks with the first sludge and 90% after 5 weeks with the second Test condition : incubation at 35 degrees C in the dark, 10 % sludge inoculum, duplicate tests Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 12.05.2004 (34) Type : anaerobic Inoculum : other: anoxic lake sediment Concentration : .1 mg/l related to Test substance .8 mg/l related to Test substance 320 UNEP PUBLICATIONS
OECD SIDS m- / p-CRESOL MIXTURE 3. ENVIRONMENTAL FATE AND PATHWAYS ID: 15831-10-4 DATE: 24.05.2004 Deg. product : yes Method : other: measured Year : 1982 GLP : no Test substance : other TS: m-cresol, purity > 95 % Deg. products : 74-82-8 200-812-7 methane Result : after 29 weeks no significant CH4 or CO2 formation observed Test condition : incubation at 20 degrees C in the dark with occasional shaking Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 12.05.2004 (34) Type : anaerobic Inoculum : other bacteria: acclimatized mixed culture of pentachlorophenol-degrading bacteria Concentration : 5 mg/l related to Test substance related to Contact time : 29 day(s) Degradation : (±) % after Result : Kinetic of testsubst. : 144 hour(s) 10 % 197 hour(s) 50 % 236 hour(s) 90 % % % Deg. product : Method : other: Die-away Test Year : 1990 GLP : no Test substance : other TS: m-cresol, gas chromatographic grade Reliability : (2) valid with restrictions No standard test procedure, but in accordance with generally accepted scientific standards and described in sufficient detail 11.02.2003 (29) Type : anaerobic Inoculum : other: phenol-enriched methanogenic culture Concentration : 100 mg/l related to Test substance related to Contact time : Degradation : 100 (±) % after 58 day(s) Result : Deg. product : yes Method : other: measured Year : 1988 GLP : no Test substance : other TS: m-cresol, no purity reported Deg. products : 74-82-8 200-812-7 methane Result : lag time 42 d, complete disappearance after 58 d, the CH4 production was 85 % of the theoretical production Test condition : nominal test concentrations m-cresol 50, 100, 150, 250, 300, 400, 500, and 700 mg/l + phenol 200 mg/l incubation at 35 °C with continuous shaking Reliability : (2) valid with restrictions UNEP PUBLICATIONS 321
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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