m-Cresol - ipcs inchem

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OECD SIDS m-CRESOL 5. TOXICITY ID: 108-39-4 DATE: 24.05.2004 specific duration of exposure: m-cresol: MRL = 0.05 mg/kg bw/d acute oral exposure Reliability : (4) not assignable 15.01.2003 (176) Remark : It is reported that certain individuals are hypersensitive to cresol (isomer not specified, no further information) Reliability : (4) not assignable Flag : Critical study for SIDS endpoint 15.01.2003 (110) Remark : Case reports: intentional or accidental oral intake of cresols (all isomers): irritation of mouth and throat, abdominal pain, vomiting, hemolytic anemia, increased heart ratem liver and kidney damage, headaches, facial paralysis, drowsiness, cramps coma and death Reliability : (2) valid with restrictions description suffers from deficiencies as the isomers are not specified Flag : Critical study for SIDS endpoint 14.01.2003 (177) (178) (179) (180) Remark : Skin depigmentation (chemical leukoderma has been reported after local exposure to cresols (isomer not specified) Reliability : (4) not assignable Flag : Critical study for SIDS endpoint 15.01.2003 (130) Remark : It is reported that skin contact has alo resulted in effects on the nervous system, liver and kidneys and caused human fatalities. Reliability : (4) not assignable Flag : Critical study for SIDS endpoint 15.01.2003 (179) Remark : A cresol solution, unintentionally poured over the trunk, caused gross hematuria, gastrointestinal bleeding, hypertension and septic shock with severe jaundice and renal failure. Reliability : (2) valid with restrictions Flag : Critical study for SIDS endpoint 15.01.2003 (181) Remark : The development of tumours in persons who had been exposed occupationally to cresol (unspecified isomer) has been reported, and two cases of transitional cell bladder carcinoma were described after longterm exposure to cresol. Since no information on exposure levels are available and since co-exposure to other substances cannot be excluded a carcinogenic potential of the cresol isomers cannot be deduced fron these cases. Reliability : (2) valid with restrictions Flag : Critical study for SIDS endpoint 15.01.2003 (182) Remark : Case report: a worker in an oil rafinery was exposed to cresol, dichlorooctane and chromic acid for a long period developed a squamous epithelial carcinoma of the vocal cords. Since no information on exposure levels is available and since co-exposure to other substances is included a 158 UNEP PUBLICATIONS
OECD SIDS m-CRESOL 5. TOXICITY ID: 108-39-4 DATE: 24.05.2004 carcinogenic potential of the cresol isomers cannot be deduced from this case report. Reliability : (4) not assignable Flag : Critical study for SIDS endpoint 15.01.2003 (179) Remark : Anomalous menstrual cycles were found and hormonal disorders were reported from women who were employed in ther production to enamelled wire or of tricresyl phosphate and were exposed to a variety of compounds, including chlorobenzenes and phosphoryl chloride. It was claimed that the incidence of perinatal child death was increased and that developmental disorders were frequent among new-born babies. since no data on exposure levels and duration of exposure are given and data on controls were not provided a relationship between the described effects and cresol exposure cannot be deduced. Reliability : (4) not assignable Flag : Critical study for SIDS endpoint 05.02.2004 (179) 5.11 ADDITIONAL REMARKS Type : Cytotoxicity Remark : m-cresol (test concentration: 0, 2, 5, 10, 20 or 50 ppm; test duration: 66 h) showed a concentration dependent decrease in growth rate and cell yield in L-M strain cells (CCL 1.2; derived from NCTC clone 939 mouse fibroblast line) in suspension culture. No effect was observed with 2 ppm. Reliability : (4) not assignable 16.01.2003 (183) Type : Cytotoxicity Remark : Cytotoxicity assay, V79 cells: the growth of V79 cells was inhibited in a dose- and time-related manner, while DNA-, RNA- and protein-syntheses were inhibited in a dose-related fashion. Reliability : (4) not assignable 16.01.2003 (184) Type : Metabolism Remark : In male Wistar rats, m-cresol was excreted as a metabolite in urine after a single i.p. injection of 0.12 ml 14C-toluene/rat. Reliability : (4) not assignable 16.01.2003 (169) Type : Metabolism Remark : m-cresol was excreted as conjugated glucuronide in urine when adminstered orally to one rabbit in a dose of 2000 mg or one hen in a dose of 1000 mg. Reliability : (4) not assignable 16.01.2003 (185) Type : Metabolism UNEP PUBLICATIONS 159
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OECD SIDS m- / p-CRESOL FOREOWRD IN
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OECD SIDS m- / p-CRESOL 11. Comment
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OECD SIDS m- / p-CRESOL of mice. In
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OECD SIDS m- / p-CRESOL SIDS Initia
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OECD SIDS m- / p-CRESOL Table 3: Es
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OECD SIDS m- / p-CRESOL m-cresol an
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OECD SIDS m- / p-CRESOL extensive s
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OECD SIDS m- / p-CRESOL et al. 1993
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OECD SIDS m- / p-CRESOL study in wh
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OECD SIDS m- / p-CRESOL Conclusion:
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OECD SIDS m- / p-CRESOL Table 5: m-
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OECD SIDS m- / p-CRESOL ≥300 ppm,
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OECD SIDS m- / p-CRESOL Atrophy and
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OECD SIDS m- / p-CRESOL p-Cresol p-
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OECD SIDS m- / p-CRESOL 3.1.7 Carci
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OECD SIDS m- / p-CRESOL weights wer
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OECD SIDS m- / p-CRESOL drowsiness,
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OECD SIDS m- / p-CRESOL and reduced
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OECD SIDS m- / p-CRESOL The most se
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OECD SIDS m- / p-CRESOL Table 14: T
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OECD SIDS m- / p-CRESOL Table 15: T
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OECD SIDS m- / p-CRESOL 5 RECOMMEND
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OECD SIDS m- / p-CRESOL BRRC (Bushy
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OECD SIDS m- / p-CRESOL Hamster Ova
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OECD SIDS m- / p-CRESOL Nobel W, Ma
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OECD SIDS m- / p-CRESOL Vernot EH,
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OECD SIDS m- / p-CRESOL Available P
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OECD SIDS m- / p-CRESOL √ informa
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OECD SIDS m-CRESOL 1. GENERAL INFOR
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OECD SIDS m-CRESOL 2. PHYSICO-CHEMI
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OECD SIDS m-CRESOL 3. ENVIRONMENTAL
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OECD SIDS m-CRESOL 4. ECOTOXICITY I
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OECD SIDS m- / p-CRESOL MIXTURE I U
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OECD SIDS m- / p-CRESOL MIXTURE 1.
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