m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
Remark : In female CFY rats, the excretion of m-cresol in urine was
increased after exposure to xylene (4000 mg/m3/6 h).
Reliability : (4) not assignable
16.01.2003 (186)
Type : Metabolism
Remark : The retention of m-cresol in male Wistar rats after the
oral administration of 25 ug/rat for 3 d (test period 7 d)
was 0.2 % (percentage of applied dose).
Reliability : (4) not assignable
16.01.2003 (26)
Type : Metabolism
Remark : After an oral application of 10 g m-cresol
within 3 days to one dog the substance was excreted
unchanged in urine.
Reliability : (4) not assignable
16.01.2003 (187)
Type : Metabolism
Remark : In an in vitro study m-cresol was hydroxylated
to 2,5-dihydroxytoluene and probably to the sulfate
conjugate of m-hydroxybenzyl alcohol with rat liver
homogenate and slices.
Reliability : (4) not assignable
16.01.2003 (188)
Type : Metabolism
Remark : in vitro: Metabolic cooperation assay for gap junctional
intercellular communication with chinese hamster cells
(V79): negative.
Reliability : (4) not assignable
16.01.2003 (189)
Remark : m-cresol inhibited the growth of chick embryo fibroblasts
(incubation for 24 h), the sublethal dose was approx. 20
mg/l and the lethal dose > 20 < 50 mg/l.
Reliability : (4) not assignable
16.01.2003 (78)
Remark : m-cresol (0.5 or 1.0 ml) showed an inhibitory effect on the
ATP-induced (50 ug) pulmonary vasoconstriction in isolated
perfused rabbit lungs.
Reliability : (4) not assignable
16.01.2003 (190)
Remark : m-cresol (550 mg/m3) showed a ciliostasis index of 0.7 to
0.75 in isolated rabbit tracheal tissue.
Reliability : (4) not assignable
16.01.2003 (191)
Remark : In a neutral red (NR) cytotoxicity assay with Bluegill
sunfish BF-2 cells, the NR50 was determined with 5.3 mM.
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