m-Cresol - ipcs inchem

OECD SIDS
m- / p-CRESOL MIXTURE
5. TOXICITY ID: 15831-10-4
DATE: 24.05.2004
temperature: 72° +/-3° F, humidity: 50 % +/-15 %,
Fluorescent light: 12 hrs/day, room air changes : 10-12
changes/hr
TYPE AND FREQUENCY OF OBSERVATION:
observed twice daily, body weight taken initially, weekly,
and at termination, feed consumption by cage recorded twice
weekly
NECROPSY AND HISTOLOGIC EXAMINATION:
necropsy and tissue collection performed for all animals. A
complete histopathologic examination was conducted on all
control animals, all animals in the highest dose group with
at least 60 % survivors at study termination, and all
aninmals in higher dose groups inclusive of early deaths.
The following organs and/or tissues were included in
complete histopathological examinations, as well as any
tissue masses, gross lesions, and associated regional lymph
nodes: adrenals, aorta, bone (sternebrae, femur, or
vertebrae, including marrow), brain, bronchi, clitoral
gland, epididymis, oesophagus, gallbladder, heart, kidney,
large intestines (caecum, colon, rectum), liver, lungs,
lymph nodes (mesenteric), mammary glands, nasal cavity and
turbinates, oral cavity, ovaries, pancreas, parathyroids,
pharynx, pituitary, preputial gland, prostate, salivary
glands, scrotal sac, seminal vesicles, skin, small intestine
(duodenum, ileum, jejunum), spleen, stomach, testes, thymus,
thyroid, tongue, trachea, tunica vaginalis, urinary bladder,
uterus and Zymbal's glands. Target organs and gross lesions
were examined at lower doses until a no-observed chemical
effect was determined. Target organs included the following:
nasal epithelium, bone marrow, forestomach, oesophagus, lung
and uterus and ovaries. Organ weights recorded for brain,
liver, right kidney, thymus, heart, and lungs of all
animals, and the right testis of all males.
STATISTICAL METHODS:
nonparametric multiple comparison test of Dunn and Shirley,
Jonckheere's test
Remark : mean compound consumption (mg/kg bw/day):
males females
0 ppm 0 0
300 ppm 50 65
1000 ppm 161 200
3000 ppm 471 604
10000 ppm 1490 1880
30000 ppm 4530 4730
Result : No effect on survival;
clinical signs of toxicity in males and females: alopecia,
dehydration, hunched posture, hypothermia, lethargy, rough
hair coat, thin appearance.
30000 ppm, males, females: weight loss; decreased feed
consumption during the first week and during the third week
(females only);
30000 and 10000 ppm: sign. decreased weight gain,
At study termination weights (w) were sign. increased:
brain (male, female: abs. and rel. w at 30000 ppm,
p