m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
06.02.2004 (123)
Species : rabbit
Concentration : undiluted
Exposure : no data
Exposure time : no data
Number of animals : 6
Vehicle :
PDII :
Result : highly irritating
Classification :
Method : other: 0.5 ml undiluted TS was applied to the intact and to the abraded
skin, time of observation: 24 and 72 hours
Year : 1969
GLP : no data
Test substance : other TS: m-Cresol, M.P.:11-12 C; B.P.: 202.8 C
Result : intact skin, erythema. edema: 24 hr: Score 4 in 6/6; 72 hr: Score 4 in 6/6
abraded skin, erythema, edema: 24 hr: Score 4 in 6/6; 72 hr: Score 4 in 6/6
no tissue destruction and/or necrosis reported, no further details reported
Summary: irritation score: 8.00/8.00
Reliability : (2) valid with restrictions
limited documentation; no information on exposure time and conditions
Flag : Critical study for SIDS endpoint
06.02.2004 (116)
Species : rabbit
Concentration : other: see method
Exposure : no data
Exposure time : no data
Number of animals : 5
Vehicle :
PDII :
Result : highly irritating
Classification :
Method : other: 0.01 ml on the skin of the rabbit belly: undiluted and 10 % solution in
acetone
Year : 1949
GLP : no
Test substance : other TS: no data on purity
Remark : undiluted m-cresol: necrosis of the skin (belly);
10 % solution in acetone: 2/5 severe erythema; 3/5 erythema
and moderate oedema
These reactions relegate to grade 6/10
Reliability : (4) not assignable
documentation insufficient for assessment
18.09.2002 (120)
Species : rabbit
Concentration : undiluted
Exposure : Semiocclusive
Exposure time : 4 hour(s)
Number of animals : 6
Vehicle :
PDII :
Result : corrosive
Classification :
Method : other: conducted in accordance with Fed. Reg.37,No.57§173.240,1972;
evaluated according to Draize, J.Pharm.Exp.Therap. 82, 1944
Year : 1974
132
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