m-Cresol - ipcs inchem

OECD SIDS
m-CRESOL
5. TOXICITY ID: 108-39-4
DATE: 24.05.2004
25 randomly selected F1 pups/sex/dose were gavaged with the appropriate
concentration of m-cresol for 11 weeks and then bred to produce F2 litters
(dosing was continued throughout mating, gestation and lactation)
F2 offspring was sacrificed at weaning.
reproductive indices: mating indices for males and females, fertility indices
for males and females, gestational index, live birth index, 4-day survival
index 7-day survival index, 21-day survival index, lactation index
Necropsy and pathology:
all F0 and F1 parental rats in all groups were subjected to a complete
necropsy ; 25 male and 25 female adults from the controls and from the
high dose groups were subjected to histopathology examination: pituitary,
vagina, uterus, ovaries. testes, epididymides, seminal vesicles, prostate
and other tissues with gross lesions identified as potentially treatment
related; any of thze above organs or tissues showing gross alterations
were also evaluated microscopically in other dose groups
A complete gross necropsy and histopathologic examination were
conducted for any parental rat dying on test
Gross necropsy included examination of the external surfaces, all orificwes,
cranila cavity, carcass, external and cut surfaces of the brain and spinal
cord, the thoracic,abdominal and pelvic cavities and their viscera, cervical
tissues and organs
a gross internal examination on any F1 and F2 pup appearing abnormal or
dying on testA complete gross necropsy and histopathologic examinations
were conducted for any animals dying on test.
statistical methods:
Levene's test,ANOVA, t-test corrected by Bonferroni method, Kruskal-
Wallis test, Mann Whitney U-test, Fishers exact test
Result : F0: pre-breed dosing period:
450 mg/kg: f,m: significant reduced body weight, signs of
toxicity: hypoactivity, ataxia, twitches, tremors,
prostration, unkempt appearance(males), urine stains,
audible respiration perinasal encrustration and perioral
wetness; mortality: 7/25 m, 5/25 f;
175 mg/kg: sacrifice due to trauma 1/25 m
F0: breed period:
450 mg/kg: maternal gestat. and lactat. bw sign. reduced,
mortality: 450 mg/kg:2/20 f; 175 mg/kg: 1/25 f;
reproductive parameters including gestational length were
unaffected by treatment
F1:
litter size, sex ratio, litter viability, pup survival were
unaffected by treatment; 450 mg/kg: reduced female pup bw
F1 pre-breed period:
slightly reduced bw in m (450, 175,30 mg/kg) and in f (450,30 mg/kg);
signs of toxicity: 450 mg/kg bw: hypoactivity, ataxia twitches, tremors
prostration urine stains, audible respiration and perioral wetness (also at
175 mg/kg
females); mortality: 450 mg/kg 3 m and 4 f;
F1 breed period:
450, 175, 30 mg/kg: reduced bw in m; maternal gestational
and lactational bw reduced in 450 mg/kg f; mortality during
gestation: 1 f each at control, 30, 175 mg/kg and 3 f at 450 mg/kg, mortality
during lactation: 3 f at 450 mg/kg
Reproductive parameters including gestational parameters
were unaffected by treatment
F2:
litter size and sex ratio unaffected; F2 pup lactational
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